Dongkwan Shin, Jeong-Ryeol Gong, Seoyoon D. Jeong, Youngwon Cho, Hwang-Phill Kim, Tae-You Kim, Kwang-Hyun Cho
{"title":"Attractor Landscape Analysis Reveals a Reversion Switch in the Transition of Colorectal Tumorigenesis (Adv. Sci. 8/2025)","authors":"Dongkwan Shin, Jeong-Ryeol Gong, Seoyoon D. Jeong, Youngwon Cho, Hwang-Phill Kim, Tae-You Kim, Kwang-Hyun Cho","doi":"10.1002/advs.202570051","DOIUrl":null,"url":null,"abstract":"<p><b>Reversion of Tumorigenesis</b></p><p>A cell fate can be quantitatively evaluated through an attractor landscape in a high-dimensional space, governed by intricate interactions of the underlying gene regulatory network. In article number 2412503, Kwang-Hyun Cho and co-workers present a systems framework, REVERT developed to identify a reversion switch in the transition of colorectal tumorigenesis, enabling the manipulation of the attractor landscape to revert cancer cells into normal cell states.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":117,"journal":{"name":"Advanced Science","volume":"12 8","pages":""},"PeriodicalIF":14.3000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/advs.202570051","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Science","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/advs.202570051","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Reversion of Tumorigenesis
A cell fate can be quantitatively evaluated through an attractor landscape in a high-dimensional space, governed by intricate interactions of the underlying gene regulatory network. In article number 2412503, Kwang-Hyun Cho and co-workers present a systems framework, REVERT developed to identify a reversion switch in the transition of colorectal tumorigenesis, enabling the manipulation of the attractor landscape to revert cancer cells into normal cell states.
期刊介绍：
Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
