Feng-Feng Pan, Qi Huang, Chu-Chung Huang, Yao Lu, Liang Cui, Lin Huang, Yihui Guan, Fang Xie, Qi-Hao Guo
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引用次数: 0
Abstract
INTRODUCTION
Various indicators of neurodegeneration (N) are used in the assessment of neuronal injury in Alzheimer's disease (AD). The heterogeneity of such indicators is less clear.
METHODS
A total of 416 individuals with different cognitive statuses were recruited for this study. Differential associations of hippocampal volume (HV), 18F-fluorodeoxyglucose positron emission tomography (FDG PET) standardized uptake value ratios (SUVRs), and plasma neurofilament light chain (NfL) levels with amyloid beta (Aβ)–tau pathology and cognitive impairment were examined.
RESULTS
HV decreased early during the high Aβ burden but tau-negative stage. FDG PET SUVRs and plasma NfL levels notably changed at tau-positive stages. HV and plasma NfL correlated with cognitive scores in the early to middle stages, while FDG PET SUVRs aligned with cognitive decline from the middle to late stages. Hippocampal atrophy and inferior parietal hypometabolism increased the risk of cognitive impairment in A+T+, while adding NfL+ had no additional impact within the distinct A/T groups.
DISCUSSION
Different indicators of N have varying relationships to AD pathology and cognitive impairment.
Highlights
Hippocampal atrophy emerges early with a high amyloid beta burden and exacerbates during the tau-positive phase.
Brain hypometabolism and elevated plasma neurofilament light chain (NfL) levels appear mainly in tau-positive stages.
Hippocampal volume and plasma NfL levels correlate with cognitive decline in the early to middle stages, while 18F-fluorodeoxyglucose positron emission tomography standardized uptake value ratios in the middle to late stages.
Hippocampal atrophy and inferior parietal hypometabolism raise the risk of cognitive impairment in amyloid/tau–positive individuals while adding NfL+ shows no additional effect.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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