Associations of hippocampal volumes, brain hypometabolism, and plasma NfL with amyloid, tau, and cognitive decline

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2025-02-24 DOI:10.1002/alz.70005

Feng-Feng Pan, Qi Huang, Chu-Chung Huang, Yao Lu, Liang Cui, Lin Huang, Yihui Guan, Fang Xie, Qi-Hao Guo

{"title":"Associations of hippocampal volumes, brain hypometabolism, and plasma NfL with amyloid, tau, and cognitive decline","authors":"Feng-Feng Pan, Qi Huang, Chu-Chung Huang, Yao Lu, Liang Cui, Lin Huang, Yihui Guan, Fang Xie, Qi-Hao Guo","doi":"10.1002/alz.70005","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Various indicators of neurodegeneration (N) are used in the assessment of neuronal injury in Alzheimer's disease (AD). The heterogeneity of such indicators is less clear.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>A total of 416 individuals with different cognitive statuses were recruited for this study. Differential associations of hippocampal volume (HV), 18F-fluorodeoxyglucose positron emission tomography (FDG PET) standardized uptake value ratios (SUVRs), and plasma neurofilament light chain (NfL) levels with amyloid beta (Aβ)–tau pathology and cognitive impairment were examined.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>HV decreased early during the high Aβ burden but tau-negative stage. FDG PET SUVRs and plasma NfL levels notably changed at tau-positive stages. HV and plasma NfL correlated with cognitive scores in the early to middle stages, while FDG PET SUVRs aligned with cognitive decline from the middle to late stages. Hippocampal atrophy and inferior parietal hypometabolism increased the risk of cognitive impairment in A+T+, while adding NfL+ had no additional impact within the distinct A/T groups.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Different indicators of N have varying relationships to AD pathology and cognitive impairment.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Hippocampal atrophy emerges early with a high amyloid beta burden and exacerbates during the tau-positive phase.</li>\n \n <li>Brain hypometabolism and elevated plasma neurofilament light chain (NfL) levels appear mainly in tau-positive stages.</li>\n \n <li>Hippocampal volume and plasma NfL levels correlate with cognitive decline in the early to middle stages, while 18F-fluorodeoxyglucose positron emission tomography standardized uptake value ratios in the middle to late stages.</li>\n \n <li>Hippocampal atrophy and inferior parietal hypometabolism raise the risk of cognitive impairment in amyloid/tau–positive individuals while adding NfL+ shows no additional effect.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 2","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70005","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70005","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

INTRODUCTION

Various indicators of neurodegeneration (N) are used in the assessment of neuronal injury in Alzheimer's disease (AD). The heterogeneity of such indicators is less clear.

METHODS

A total of 416 individuals with different cognitive statuses were recruited for this study. Differential associations of hippocampal volume (HV), 18F-fluorodeoxyglucose positron emission tomography (FDG PET) standardized uptake value ratios (SUVRs), and plasma neurofilament light chain (NfL) levels with amyloid beta (Aβ)–tau pathology and cognitive impairment were examined.

RESULTS

HV decreased early during the high Aβ burden but tau-negative stage. FDG PET SUVRs and plasma NfL levels notably changed at tau-positive stages. HV and plasma NfL correlated with cognitive scores in the early to middle stages, while FDG PET SUVRs aligned with cognitive decline from the middle to late stages. Hippocampal atrophy and inferior parietal hypometabolism increased the risk of cognitive impairment in A+T+, while adding NfL+ had no additional impact within the distinct A/T groups.

DISCUSSION

Different indicators of N have varying relationships to AD pathology and cognitive impairment.

Highlights

Hippocampal atrophy emerges early with a high amyloid beta burden and exacerbates during the tau-positive phase.
Brain hypometabolism and elevated plasma neurofilament light chain (NfL) levels appear mainly in tau-positive stages.
Hippocampal volume and plasma NfL levels correlate with cognitive decline in the early to middle stages, while 18F-fluorodeoxyglucose positron emission tomography standardized uptake value ratios in the middle to late stages.
Hippocampal atrophy and inferior parietal hypometabolism raise the risk of cognitive impairment in amyloid/tau–positive individuals while adding NfL+ shows no additional effect.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

海马体积、脑低代谢和血浆NfL与淀粉样蛋白、tau蛋白和认知能力下降的关系

神经退行性变(N)的各种指标被用于评估阿尔茨海默病（AD）的神经元损伤。这些指标的异质性不太清楚。方法共招募416名具有不同认知状态的个体进行研究。研究海马体积（HV）、18f -氟脱氧葡萄糖正电子发射断层扫描（FDG PET）标准化摄取值比（SUVRs）和血浆神经丝轻链（NfL）水平与淀粉样蛋白β (Aβ) -tau病理和认知障碍的差异关系。结果在Aβ高负荷但tau阴性期，HV较早下降。FDG PET suv和血浆NfL水平在tau阳性阶段发生显著变化。HV和血浆NfL与早期到中期的认知评分相关，而FDG PET SUVRs与中期到晚期的认知下降相关。海马萎缩和下顶叶低代谢增加了A+T+组认知功能障碍的风险，而在不同的A/T组中添加NfL+没有额外的影响。不同的N指标与AD病理和认知障碍的关系不同。海马萎缩出现早期，淀粉样蛋白高负荷，并在tau阳性期加剧。脑代谢降低和血浆神经丝轻链（NfL）水平升高主要出现在tau阳性阶段。海马体积和血浆NfL水平与早期到中期的认知能力下降相关，而18f -氟脱氧葡萄糖正电子发射断层扫描标准化了中期到晚期的摄取值比率。在淀粉样蛋白/tau阳性个体中，海马萎缩和下顶叶低代谢会增加认知障碍的风险，而添加NfL+则没有额外的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.