Tao Liao, Jinxiu Liu, Jia Chen, Zhongjia Liu, Guolie Xie, Ning Guo, Ying Kuang, Linghui Dian, Cao Li, Yun Liu
{"title":"Cu<sub>2-<i>x</i></sub>O@Ti<sub>3</sub>C<sub>2</sub> Integrated Photothermal Nanofibers with Antibacterial, Anti-Inflammatory, and Hemostatic Properties for Promoting Infected Diabetic Wound Healing.","authors":"Tao Liao, Jinxiu Liu, Jia Chen, Zhongjia Liu, Guolie Xie, Ning Guo, Ying Kuang, Linghui Dian, Cao Li, Yun Liu","doi":"10.1021/acsbiomaterials.4c01936","DOIUrl":null,"url":null,"abstract":"<p><p>Infected diabetic wounds represent a significant challenge in clinical care due to persistent inflammation and impaired healing. To address these issues, the development of novel wound dressings with both antibacterial and reactive oxygen species (ROS) scavenging properties is essential. Herein, we prepare a novel wound dressing composed of Cu<sub>2-<i>x</i></sub>O nanoparticles decorated on Ti<sub>3</sub>C<sub>2</sub> MXene (Cu<sub>2-<i>x</i></sub>O@Ti<sub>3</sub>C<sub>2</sub>) and integrate it into a poly(vinyl alcohol) (PVA) matrix to form electrospun nanofibers (Cu<sub>2-<i>x</i></sub>O@Ti<sub>3</sub>C<sub>2</sub>@PVA). Cu<sub>2-<i>x</i></sub>O@Ti<sub>3</sub>C<sub>2</sub> exhibits remarkable photothermal conversion efficiency and effective ROS scavenging properties. In vitro experiments demonstrated that Cu<sub>2-<i>x</i></sub>O@Ti<sub>3</sub>C<sub>2</sub> effectively kills bacteria upon near-infrared (NIR) irradiation, which can be attributed to the photothermal therapy (PTT) effect of Ti<sub>3</sub>C<sub>2</sub>. At the same time, the ROS scavenging abilities of both Ti<sub>3</sub>C<sub>2</sub> and Cu<sub>2-<i>x</i></sub>O endow Cu<sub>2-<i>x</i></sub>O@Ti<sub>3</sub>C<sub>2</sub> with significant in vitro anti-inflammatory effects. As a promising wound dressing, in vivo studies validated the high efficacy of Cu<sub>2-<i>x</i></sub>O@Ti<sub>3</sub>C<sub>2</sub>@PVA in promoting hemostasis, exerting antibacterial activity, reducing inflammation, and accelerating the healing process of diabetic wounds. This innovative approach provides a comprehensive solution to the multifaceted challenges of diabetic wound healing and paves the way for improved clinical outcomes.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4000,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Biomaterials Science & Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1021/acsbiomaterials.4c01936","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0
Abstract
Infected diabetic wounds represent a significant challenge in clinical care due to persistent inflammation and impaired healing. To address these issues, the development of novel wound dressings with both antibacterial and reactive oxygen species (ROS) scavenging properties is essential. Herein, we prepare a novel wound dressing composed of Cu2-xO nanoparticles decorated on Ti3C2 MXene (Cu2-xO@Ti3C2) and integrate it into a poly(vinyl alcohol) (PVA) matrix to form electrospun nanofibers (Cu2-xO@Ti3C2@PVA). Cu2-xO@Ti3C2 exhibits remarkable photothermal conversion efficiency and effective ROS scavenging properties. In vitro experiments demonstrated that Cu2-xO@Ti3C2 effectively kills bacteria upon near-infrared (NIR) irradiation, which can be attributed to the photothermal therapy (PTT) effect of Ti3C2. At the same time, the ROS scavenging abilities of both Ti3C2 and Cu2-xO endow Cu2-xO@Ti3C2 with significant in vitro anti-inflammatory effects. As a promising wound dressing, in vivo studies validated the high efficacy of Cu2-xO@Ti3C2@PVA in promoting hemostasis, exerting antibacterial activity, reducing inflammation, and accelerating the healing process of diabetic wounds. This innovative approach provides a comprehensive solution to the multifaceted challenges of diabetic wound healing and paves the way for improved clinical outcomes.
期刊介绍：
ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics:
Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology
Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions
Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis
Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering
Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends
Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring
Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration
Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials
Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
