Impaired Sensitivity to Thyroid Hormones is Associated with Lower Heart Rate in the Euthyroid Population.

IF 5.6 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Heart rhythm Pub Date : 2025-02-20 DOI:10.1016/j.hrthm.2025.02.028

Guojie Ye, Yingyue Zhang, Le Peng, Zhenze Yu, Yunhe Bai, Meishan Wu, Dan Lu, Chunhua Ding

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Abstract

Background: The association of thyroid hormone sensitivity with heart rate remains unclear.

Objective: This study aims to elucidate the relationship between impaired thyroid hormone sensitivity and lower heart rate in the euthyroid population.

Methods: A total of 550 participants were included. Heart rate and serum biochemicals were measured. Thyroid hormone sensitivity indices were calculated by TSH index (TSHI), thyrotropin thyroxine resistance index (TT4RI), thyroid feedback quantile-based index (TFQI), Chinese-referenced parametric TFQI (PTFQI) and the ratio of FT3 to FT4 (FT3/FT4). Logistic regression analyses were applied to explore the relationship between indices of thyroid hormone sensitivity and heart rate.

Results: TSHI, TT4RI, TFQI, PTFQI were higher, and FT3/FT4 was lower in participants with heart rates ≤ 60bmp (all P < 0.001). Subjects with increased TSHI, TT4RI, TFQI, PTFQI and reduced FT3/FT4 had lower heart rates (≤60bmp) (all P for trend < 0.001). Odds ratios (ORs) (95% confidence intervals [CIs]) for TSHI, TT4RI, TFQI, PTFQI and FT3/FT4 in the highest quartile were respectively 2.090 (1.092-4.000), 2.240 (1.151-4.361), 2.014 (1.043-3.887), 2.163 (1.123-4.166) and 0.498, (0.249-0.996) compared with the lowest quartile after adjusted for gender, age, body mass index (BMI), smoking, drinking, hypertension, diabetes, coronary artery disease, glycated hemoglobin, total cholesterol, low-density lipoprotein, triglycerides.

Conclusion: Impaired sensitivity to thyroid hormones was associated with lower heart rate in euthyroid subjects. Future large-scale studies are needed to confirm our findings.

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来源期刊

Heart rhythm 医学-心血管系统

CiteScore

10.50

自引率

5.50%

发文量

1465

审稿时长

24 days

期刊介绍： HeartRhythm, the official Journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, is a unique journal for fundamental discovery and clinical applicability. HeartRhythm integrates the entire cardiac electrophysiology (EP) community from basic and clinical academic researchers, private practitioners, engineers, allied professionals, industry, and trainees, all of whom are vital and interdependent members of our EP community. The Heart Rhythm Society is the international leader in science, education, and advocacy for cardiac arrhythmia professionals and patients, and the primary information resource on heart rhythm disorders. Its mission is to improve the care of patients by promoting research, education, and optimal health care policies and standards.