Metabolomic profiling of plasma from glioma and meningioma patients based on two complementary mass spectrometry techniques.

IF 3.5 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Metabolomics Pub Date : 2025-02-22 DOI:10.1007/s11306-025-02231-5
Adrian Godlewski, Patrycja Mojsak, Tomasz Pienkowski, Tomasz Lyson, Zenon Mariak, Joanna Reszec, Karol Kaminski, Marcin Moniuszko, Adam Kretowski, Michal Ciborowski
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引用次数: 0

Abstract

Introduction: Extracranial and intracranial tumors are a diverse group of malignant and benign neoplasms, influenced by multiple factors. Given the complex nature of these tumors and usually late or accidental diagnosis, minimally invasive, rapid, early, and accurate diagnostic methods are urgently required. Metabolomics offers promising insights into central nervous system tumors by uncovering distinctive metabolic changes linked to tumor development.

Objectives: This study aimed to elucidate the role of altered metabolites and the associated biological pathways implicated in the development of gliomas and meningiomas.

Methods: The study was conducted on 95 patients with gliomas, 68 patients with meningiomas, and 71 subjects as a control group. The metabolic profiling of gliomas and meningiomas achieved by integrating untargeted metabolomic analysis based on GC-MS and targeted analysis performed using LC-MS/MS represents the first comprehensive study. Three comparisons (gliomas or meningiomas vs. controls as well as gliomas vs. meningiomas) were performed to reveal statistically significant metabolites.

Results: Comparative analysis revealed 97, 56, and 27 significant metabolites for gliomas vs. controls, meningiomas vs. controls and gliomas vs. meningiomas comparison, respectively. Moreover, among above mentioned comparisons unique metabolites involved in arginine biosynthesis and metabolism, the Krebs cycle, and lysine degradation pathways were found. Notably, 2-aminoadipic acid has been identified as a metabolite that can be used in distinguishing two tumor types.

Conclusions: Our results provide a deeper understanding of the metabolic changes associated with brain tumor development and progression.

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来源期刊
Metabolomics
Metabolomics 医学-内分泌学与代谢
CiteScore
6.60
自引率
2.80%
发文量
84
审稿时长
2 months
期刊介绍: Metabolomics publishes current research regarding the development of technology platforms for metabolomics. This includes, but is not limited to: metabolomic applications within man, including pre-clinical and clinical pharmacometabolomics for precision medicine metabolic profiling and fingerprinting metabolite target analysis metabolomic applications within animals, plants and microbes transcriptomics and proteomics in systems biology Metabolomics is an indispensable platform for researchers using new post-genomics approaches, to discover networks and interactions between metabolites, pharmaceuticals, SNPs, proteins and more. Its articles go beyond the genome and metabolome, by including original clinical study material together with big data from new emerging technologies.
期刊最新文献
Identification of metabolite-disease associations based on knowledge graph. Metabolic and proteomic analysis of a medicinal morel (Morchella elata) from Western Himalayas, Kashmir. Metabolomic profiling of plasma from glioma and meningioma patients based on two complementary mass spectrometry techniques. Evaluation of solutions for stabilizing feces in metabolomics studies using GC × GC-TOFMS. Harnessing NMR technology for enhancing field crop improvement: applications, challenges, and future perspectives.
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