Test-retest reliability of coupling between cerebrospinal fluid flow and global brain activity after normal sleep and sleep deprivation

IF 4.5 2区医学 Q1 NEUROIMAGING NeuroImage Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI:10.1016/j.neuroimage.2025.121097

Weiwei Zhao , Joy Rao , Ruosi Wang , Ya Chai , Tianxin Mao , Peng Quan , Yao Deng , Wenwen Chen , Shilei Wang , Bowen Guo , Qingyun Zhang , Hengyi Rao

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Abstract

The glymphatic system (GS) plays a key role in maintaining brain homeostasis by clearing metabolic waste during sleep, with the coupling between global blood-oxygen-level-dependent (gBOLD) and cerebrospinal fluid (CSF) signals serving as a potential marker for glymphatic clearance function. However, the test-retest reliability and spatial heterogeneity of gBOLD-CSF coupling after different sleep conditions remain unclear. In this study, we assessed the test-retest reliability of gBOLD-CSF coupling following either normal sleep or total sleep deprivation (TSD) in 64 healthy adults under controlled laboratory conditions. The reliability was high after normal sleep (ICC = 0.763) but decreased following TSD (ICC = 0.581). Moreover, spatial heterogeneity was evident in participants with normal sleep, with lower-order networks (visual, somatomotor, and attention) showing higher ICC values compared to higher-order networks (default-mode, limbic, and frontoparietal). This spatial variation was less distinct in the TSD group. These results demonstrate the robustness of the gBOLD-CSF coupling method and emphasize the significance of considering sleep history in glymphatic function research.

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正常睡眠和睡眠剥夺后脑脊液流量和整体脑活动耦合的重测可靠性。

淋巴系统（glymphatic system， GS）通过清除睡眠期间的代谢废物在维持大脑稳态中发挥关键作用，全球血氧水平依赖性（gBOLD）和脑脊液（CSF）信号之间的耦合可作为淋巴清除功能的潜在标记物。然而，不同睡眠条件下gBOLD-CSF耦合的重测信度和空间异质性尚不清楚。在这项研究中，我们在受控的实验室条件下评估了64名健康成年人在正常睡眠或完全睡眠剥夺（TSD）后gBOLD-CSF耦合的重测可靠性。正常睡眠后的信度较高（ICC = 0.763），但TSD后的信度降低（ICC = 0.581）。此外，在正常睡眠的参与者中，空间异质性很明显，与高阶网络（默认模式、边缘和额顶叶）相比，低阶网络（视觉、躯体运动和注意力）显示出更高的ICC值。这种空间差异在TSD组中不太明显。这些结果证明了gBOLD-CSF耦合方法的稳健性，并强调了在淋巴功能研究中考虑睡眠历史的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.