{"title":"Aberrant miRNA expression and protein arginine methyltransferase 5 (PRMT5) in cancer: A review","authors":"Saïd Sif, Majdi Al Alawneh","doi":"10.1016/j.bbamcr.2025.119923","DOIUrl":null,"url":null,"abstract":"<div><div>The search for important factors involved in triggering and promoting cancer cell growth and survival has led to the identification of key players, including transcription factors, chromatin remodelers, epigenetic modifying enzymes, signaling molecules, and miRNAs. However, the interplay and crosstalk between some of these factors and the impact they have on tumorigenesis remains largely unexplored. In this review, we focus on type II protein arginine methyltransferase 5 (PRMT5)-mediated epigenetic silencing and its regulatory tumor suppressor miRNAs, as well as the mechanisms by which circular PRMT5 RNA (circ-PRMT5) promotes cancer cell proliferation and survival.</div></div>","PeriodicalId":8754,"journal":{"name":"Biochimica et biophysica acta. Molecular cell research","volume":"1872 3","pages":"Article 119923"},"PeriodicalIF":4.6000,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et biophysica acta. Molecular cell research","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S016748892500028X","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The search for important factors involved in triggering and promoting cancer cell growth and survival has led to the identification of key players, including transcription factors, chromatin remodelers, epigenetic modifying enzymes, signaling molecules, and miRNAs. However, the interplay and crosstalk between some of these factors and the impact they have on tumorigenesis remains largely unexplored. In this review, we focus on type II protein arginine methyltransferase 5 (PRMT5)-mediated epigenetic silencing and its regulatory tumor suppressor miRNAs, as well as the mechanisms by which circular PRMT5 RNA (circ-PRMT5) promotes cancer cell proliferation and survival.
期刊介绍：
BBA Molecular Cell Research focuses on understanding the mechanisms of cellular processes at the molecular level. These include aspects of cellular signaling, signal transduction, cell cycle, apoptosis, intracellular trafficking, secretory and endocytic pathways, biogenesis of cell organelles, cytoskeletal structures, cellular interactions, cell/tissue differentiation and cellular enzymology. Also included are studies at the interface between Cell Biology and Biophysics which apply for example novel imaging methods for characterizing cellular processes.
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