One 3D Zn-MOF for Fluorescence Sensing and Visualization Detection of Biomarker and Antibiotic

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED Applied Organometallic Chemistry Pub Date : 2025-02-24 DOI:10.1002/aoc.70079

Tingting Liu, Mengna Ji, Hongguo Hao, Jianmin Dou, Hui Yan, Jingjing Jiang, Yunwu Li, Suna Wang

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Abstract

One 3D Zn-MOF, namely, {[Zn₂(L)(OH)(DMF)]}_n was selected based on the flexible ether oxygen carboxylic acid 3-(3,5-dicarboxylatobenzyloxy)benzoic acid (H₃L). Zn-MOF was able to specifically recognize the biomarker methylmalonic acid (MMA) and antibiotic tetracycline (TC) through fluorescence enhancement and ratio mechanism, with the detection limits (LOD) as low as 1.29 and 0.26 μM, respectively. It also has high selectivity and rapid response characteristics. In particular, the visual detection was significantly enhanced in the presence of Tb³⁺ through antenna effect. To explore the potential application, fluorescent test strips and mixed matrix membrane (MMM) were successfully prepared to realize visual detection. The recovery rates of MMA and TC in simulated urine and actual water systems were 95.3%–100.5% and 93.5%–94.7%, respectively, indicating that Zn-MOF provided the possibility for detecting biomarker and antibiotic in practical systems.

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一种用于生物标志物和抗生素荧光传感和可视化检测的3D Zn-MOF

以柔性醚氧羧酸3-（3,5-二羧基latobobooxy）苯甲酸（H3L）为原料，选择了1种三维Zn-MOF，即{[Zn2(L)(OH)(DMF)]}n。Zn-MOF能够通过荧光增强和比值机制特异性识别生物标志物甲基丙二酸（MMA）和抗生素四环素（TC），检出限（LOD）分别低至1.29和0.26 μM。它还具有高选择性和快速响应的特点。特别是在Tb3+存在的情况下，通过天线效应，视觉检测明显增强。为了探索潜在的应用前景，成功制备了荧光试纸条和混合基质膜（MMM），实现了视觉检测。MMA和TC在模拟尿液和实际水系统中的回收率分别为95.3% ~ 100.5%和93.5% ~ 94.7%，表明Zn-MOF为在实际系统中检测生物标志物和抗生素提供了可能。

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.