Synthesis, Characterization, DFT, TEM, Anticancer, Antibacterial, and Electrical Properties Studies of Novel VO(II), Cu(II), Ru(III), and Ag(I) Complexes With Hydrazone Derivatives

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED Applied Organometallic Chemistry Pub Date : 2025-02-24 DOI:10.1002/aoc.70073

Ehab M. Abdalla, Samar A. Aly, Alia H. Salama, Safaa S. Hassan, Ahmed M. Mongy, Tarek A. Salem, Perihan A. Khalf-Alla

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Abstract

Four new VO(II), Cu(II), Ru(III), and Ag(I) chelates were created from the ligand, 2-(phenylglycyl)-N-(p-tolyl)hydrazine-1-carbothioamide(H₂L). The structures of the new compounds were investigated using analytical and spectroscopic techniques and supported by the theoretical DFT study. In addition, all compounds exhibited strong anticancer effects against liver (Hep-G2), breast (MCF-7), and colon (HCT-116) human cancer cell lines. VO(II) complex observed the greatest activity with IC₅₀ reached to 14, 19, and 20 μM against Hep-G2, MCF-7, and HCT-116 cell lines, respectively. Molecular docking confirmed the resulted anticancer results. Also, the compounds observed microbial growth inhibition against S. pyogenes and E. coli organisms. The transmission electron microscope (TEM) demonstrated that the pure ligand's particle size decreased when it formed complexes with various metals. The electrical examination of complexes involved measuring their conductivity and dielectric characteristics to explore their application in electrical devices.

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新型含腙衍生物的VO（II）、Cu（II）、Ru（III）和Ag(I)配合物的合成、表征、DFT、TEM、抗癌、抗菌和电性能研究

以2-（苯基甘酰基）- n -（对甲基）肼-1-碳硫酰胺（H2L）为配体，合成了4种新的VO（II）、Cu（II）、Ru（III）和Ag(I)螯合物。利用分析和光谱技术研究了新化合物的结构，并得到了理论DFT研究的支持。此外，所有化合物对肝癌（Hep-G2）、乳腺癌（MCF-7）和结肠癌（HCT-116）人类癌细胞系都有很强的抗癌作用。VO（II）配合物对Hep-G2、MCF-7和HCT-116细胞株的IC50分别达到14、19和20 μM，活性最强。分子对接证实了结果的抗癌效果。此外，化合物对化脓性葡萄球菌和大肠杆菌的微生物生长也有抑制作用。透射电子显微镜（TEM）分析表明，纯配体与各种金属形成配合物时，其粒径减小。络合物的电气检测包括测量其电导率和介电特性，以探索其在电气器件中的应用。

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.