Synthesis, Characterization, DFT, TEM, Anticancer, Antibacterial, and Electrical Properties Studies of Novel VO(II), Cu(II), Ru(III), and Ag(I) Complexes With Hydrazone Derivatives

IF 3.7 2区化学 Q2 CHEMISTRY, APPLIED Applied Organometallic Chemistry Pub Date : 2025-02-24 DOI:10.1002/aoc.70073

Ehab M. Abdalla, Samar A. Aly, Alia H. Salama, Safaa S. Hassan, Ahmed M. Mongy, Tarek A. Salem, Perihan A. Khalf-Alla

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引用次数: 0

Abstract

Four new VO(II), Cu(II), Ru(III), and Ag(I) chelates were created from the ligand, 2-(phenylglycyl)-N-(p-tolyl)hydrazine-1-carbothioamide(H₂L). The structures of the new compounds were investigated using analytical and spectroscopic techniques and supported by the theoretical DFT study. In addition, all compounds exhibited strong anticancer effects against liver (Hep-G2), breast (MCF-7), and colon (HCT-116) human cancer cell lines. VO(II) complex observed the greatest activity with IC₅₀ reached to 14, 19, and 20 μM against Hep-G2, MCF-7, and HCT-116 cell lines, respectively. Molecular docking confirmed the resulted anticancer results. Also, the compounds observed microbial growth inhibition against S. pyogenes and E. coli organisms. The transmission electron microscope (TEM) demonstrated that the pure ligand's particle size decreased when it formed complexes with various metals. The electrical examination of complexes involved measuring their conductivity and dielectric characteristics to explore their application in electrical devices.

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来源期刊

Applied Organometallic Chemistry 化学-无机化学与核化学

CiteScore

7.80

自引率

10.30%

发文量

408

审稿时长

2.2 months

期刊介绍： All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.