{"title":"Investigating 1,2,3-Bistriazole-Functionalized Sn (II) Chemosensors for COX-2 Detection","authors":"Gurjaspreet Singh, Vinit Yadav, Anurag Dalal, Devina Sharma, Mithun, Jigmat Stanzin, Sumesh Khurana, Manraj Singh, Aman Bhalla","doi":"10.1002/aoc.70085","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>This article, describe the synthesis of 4-ethynylaniline derived 1,2,3-bis-triazole (<b>3</b>) via Cu(I) catalyzed click reaction and various spectroscopic methods such as FT-IR, TGA, <sup>1</sup>H and <sup>13</sup>C NMR, and mass spectrometry are used for characterization. The probe <b>3</b> exhibits high sensitivity and selectivity to Sn (II) in UV–visible spectroscopy, with a limit of detection of 27 μM and association constant 8.32 MM<sup>−1</sup>, respectively. The synthetic sensor practical application was further explored by detecting Sn (II) in real sample analysis. The computational analysis using the DFT techniques shows the binding mechanism of sensor with Sn (II). Additionally, molecular docking investigation was conducted against cyclooxygenase-2 to shows the anti-inflammatory properties of the synthesized ligand having a good binding energy −10.26 Kcal mol<sup>−1</sup>.</p>\n </div>","PeriodicalId":8344,"journal":{"name":"Applied Organometallic Chemistry","volume":"39 3","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Organometallic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/aoc.70085","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
引用次数: 0
Abstract
This article, describe the synthesis of 4-ethynylaniline derived 1,2,3-bis-triazole (3) via Cu(I) catalyzed click reaction and various spectroscopic methods such as FT-IR, TGA, 1H and 13C NMR, and mass spectrometry are used for characterization. The probe 3 exhibits high sensitivity and selectivity to Sn (II) in UV–visible spectroscopy, with a limit of detection of 27 μM and association constant 8.32 MM−1, respectively. The synthetic sensor practical application was further explored by detecting Sn (II) in real sample analysis. The computational analysis using the DFT techniques shows the binding mechanism of sensor with Sn (II). Additionally, molecular docking investigation was conducted against cyclooxygenase-2 to shows the anti-inflammatory properties of the synthesized ligand having a good binding energy −10.26 Kcal mol−1.
期刊介绍：
All new compounds should be satisfactorily identified and proof of their structure given according to generally accepted standards. Structural reports, such as papers exclusively dealing with synthesis and characterization, analytical techniques, or X-ray diffraction studies of metal-organic or organometallic compounds will not be considered. The editors reserve the right to refuse without peer review any manuscript that does not comply with the aims and scope of the journal. Applied Organometallic Chemistry publishes Full Papers, Reviews, Mini Reviews and Communications of scientific research in all areas of organometallic and metal-organic chemistry involving main group metals, transition metals, lanthanides and actinides. All contributions should contain an explicit application of novel compounds, for instance in materials science, nano science, catalysis, chemical vapour deposition, metal-mediated organic synthesis, polymers, bio-organometallics, metallo-therapy, metallo-diagnostics and medicine. Reviews of books covering aspects of the fields of focus are also published.
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