Association Between a New Model of Insulin Sensitivity and Hypertension in Patients With Type 2 Diabetes: A Cross-Sectional Study

Abstract

Type 2 diabetes (T2D) and hypertension often coexist, and insulin resistance (IR) plays an important role in their pathological progression. An increasing number of studies have focused on the relationship between different IR indices and hypertension. A natural log transformation of the glucose disposal rate (log_e GDR) has been proposed as a new model for insulin sensitivity in patients with T2D. The study aimed to explore the relationship between log_e GDR and hypertension in T2D patients. This cross-sectional study included 1544 Chinese T2D patients. Clinical and biochemical characteristics were collected. The log_e GDR was calculated based on triglycerides, urinary albumin to creatinine ratio, gamma-glutamyl transferase, and body mass index. Patients were categorized into hypertension and nonhypertension groups stratified by gender. Among both females and males, compared with the nonhypertension group, the level of log_e GDR was significantly decreased in the hypertension group (both p < 0.001). As the log_e GDR increased, the levels of systolic and diastolic blood pressure, and the prevalence of hypertension were obviously increased (all p < 0.001). Univariate analysis displayed that log_e GDR was negatively related to hypertension (correlation coefficient: −0.243, p < 0.001 in females; correlation coefficient: −0.181, p < 0.001 in males). Furthermore, the logistic regression analysis showed that log_e GDR was independently associated with hypertension (OR: 0.456; 95% CI: 0.224–0.927 in females; OR: 0.544; 95% CI: 0.314–0.941 in males). This study revealed that log_e GDR was closely related to hypertension, which might help monitor and manage hypertension in T2D patients.