Plasma and neuroimaging biomarkers of small vessel disease and Alzheimer's disease in a diverse cohort: MESA.

medRxiv : the preprint server for health sciences Pub Date : 2025-02-14 DOI:10.1101/2025.02.11.25322109

Samuel N Lockhart, Courtney L Sutphen, Jordan Tanley, Fernando Gonzalez-Ortiz, Przemysław R Kac, Mohamad Habes, Susan R Heckbert, Nicholas J Ashton, Michelle M Mielke, Robert Koeppe, Marc D Rudolph, Christopher T Whitlow, Kevin D Hiatt, Suzanne Craft, Thomas C Register, Kathleen M Hayden, Stephen R Rapp, Bonnie C Sachs, Henrik Zetterberg, Kaj Blennow, Thomas K Karikari, Timothy M Hughes

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Abstract

Introduction: Little is known about how Alzheimer's disease (AD) plasma biomarkers relate to cerebral small vessel disease (cSVD) neuroimaging biomarkers.

Methods: The study involved 251 Wake Forest Multi-Ethnic Study of Atherosclerosis (MESA) Exam 6 participants with plasma AD biomarkers, MRI, amyloid PET, and adjudicated cognitive status. Multivariable models examined cross-sectional relationships between plasma and neuroimaging biomarkers, considering comorbidities.

Results: Lower Aβ42/Aβ40, and higher GFAP, NfL, and p-tau217 were associated with greater neurodegeneration. Lower plasma Aβ42/Aβ40 and higher p-tau217 and p-tau231 were associated with greater Aβ PET deposition. NfL was positively associated with WMH and WM Free Water. P-tau measures were positively associated with WM Free Water. Lower Aβ42/Aβ40 was associated with presence of microbleeds. GFAP was positively associated with WMH.

Discussion: We observed expected associations of plasma biomarkers with cognitive status and imaging biomarkers. GFAP, NfL, p-tau181, p-tau217, and p-tau231 are associated with cSVD in addition to AD-related pathology.

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简介：人们对阿尔茨海默病（AD）血浆生物标志物与脑小血管疾病（cSVD）神经影像生物标志物之间的关系知之甚少：人们对阿尔茨海默病（AD）血浆生物标志物与脑小血管病（cSVD）神经影像生物标志物之间的关系知之甚少：该研究涉及 251 名维克森林多种族动脉粥样硬化研究（MESA）6 次考试的参与者，他们的血浆 AD 生物标志物、核磁共振成像、淀粉样蛋白 PET 和认知状况均已判定。多变量模型检查了血浆和神经影像生物标志物之间的横截面关系，并考虑了合并症：结果：较低的 Aβ42/Aβ40、较高的 GFAP、NfL 和 p-tau217 与较严重的神经退行性变相关。较低的血浆 Aβ42/Aβ40、较高的 p-tau217 和 p-tau231 与较多的 Aβ PET 沉积有关。NfL与WMH和WM游离水呈正相关。P-tau测量值与WM自由水呈正相关。较低的 Aβ42/Aβ40 与微出血相关。GFAP与WMH呈正相关：讨论：我们观察到血浆生物标志物与认知状态和成像生物标志物的预期关联。GFAP、NfL、p-tau181、p-tau217和p-tau231除了与AD相关的病理变化有关外，还与cSVD有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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medRxiv : the preprint server for health sciences

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