Taeyang Do , Geun Ho Kim , Ramon Rios , Jung Woon Yang
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引用次数: 0
Abstract
β-Fluoroamines are valuable entities in pharmaceutical, medicinal chemistry, and biochemistry. This review highlights the recent advances in transition metal-free and organocatalytic methods for the regio- and stereoselective synthesis of chiral 1,2-aminofluorinated alkyl compounds. Synthetic methods for direct 1,2- and 1,4-aminofluorination, along with fluorocyclization reactions, are described an enantioselective manner, with a focus on organocatalytic reactions involving a Lewis base, phase-transfer, and hypervalent iodine catalysis. The results of a comprehensive mechanistic study of each reaction are presented, along with a detailed perspective.
期刊介绍：
Molecular Catalysis publishes full papers that are original, rigorous, and scholarly contributions examining the molecular and atomic aspects of catalytic activation and reaction mechanisms. The fields covered are:
Heterogeneous catalysis including immobilized molecular catalysts
Homogeneous catalysis including organocatalysis, organometallic catalysis and biocatalysis
Photo- and electrochemistry
Theoretical aspects of catalysis analyzed by computational methods
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