The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma.

IF 1.2 Q4 HEMATOLOGY Hematology Reports Pub Date : 2025-01-24 DOI:10.3390/hematolrep17010005

Charles J Weeks, Mohammad Mian, Michael Stokes, Matthew Gold, Anvay Shah, Rohan Vuppala, Katherine J Kim, Abigayle B Simon, Jorge Cortes, Anand Jillela, Vamsi Kota

{"title":"The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma.","authors":"Charles J Weeks, Mohammad Mian, Michael Stokes, Matthew Gold, Anvay Shah, Rohan Vuppala, Katherine J Kim, Abigayle B Simon, Jorge Cortes, Anand Jillela, Vamsi Kota","doi":"10.3390/hematolrep17010005","DOIUrl":null,"url":null,"abstract":"Background: An autologous stem cell transplant (ASCT) is the standard of care for eligible patients with multiple myeloma (MM). However, the success of ASCT largely hinges on efficient mobilization; thus, a thorough analysis of factors that may affect mobilization is essential.Methods: The study consists of a single-center, retrospective chart review of 292 adult patients undergoing their first or second autologous transplantation for MM from 2016 to 2023. Patient demographics, serum lab values at the pre-collection evaluation visit, total stem cell capture (TC) in CD34/kg × 106 stem cell capture on the first day of apheresis (FC) in CD34/kg × 106, and the total number of days of apheresis (DOA) were retrieved from the electronic medical record (EMR).Results: Individuals with high folate levels experienced less DOA (1.43 ± 0.61) compared to those with normal folate levels (1.68 ± 0.82, p = 0.013). The high-folate group had a greater FC (3.26 ± 1.07) compared to the normal-folate group (2.88 ± 1.13, p = 0.013). High ferritin levels were associated with more DOA (1.79 ± 0.89) compared to the normal-ferritin group (1.51 ± 0.67, p = 0.034). Moderate anemia was significantly associated with decreased FC (p = 0.023) and increased DOA (p = 0.030). Abnormal hemoglobin (Hgb), ferritin, and folate statuses did not exhibit significant differences in survival analysis.Conclusions: The findings reveal that folate, ferritin, and Hgb levels are significantly associated with apheresis outcomes, offering guidance for optimizing stem cell mobilization in patients with MM.","PeriodicalId":12829,"journal":{"name":"Hematology Reports","volume":"17 1","pages":""},"PeriodicalIF":1.2000,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11855912/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hematology Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/hematolrep17010005","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: An autologous stem cell transplant (ASCT) is the standard of care for eligible patients with multiple myeloma (MM). However, the success of ASCT largely hinges on efficient mobilization; thus, a thorough analysis of factors that may affect mobilization is essential.

Methods: The study consists of a single-center, retrospective chart review of 292 adult patients undergoing their first or second autologous transplantation for MM from 2016 to 2023. Patient demographics, serum lab values at the pre-collection evaluation visit, total stem cell capture (TC) in CD34/kg × 10⁶ stem cell capture on the first day of apheresis (FC) in CD34/kg × 10⁶, and the total number of days of apheresis (DOA) were retrieved from the electronic medical record (EMR).

Results: Individuals with high folate levels experienced less DOA (1.43 ± 0.61) compared to those with normal folate levels (1.68 ± 0.82, p = 0.013). The high-folate group had a greater FC (3.26 ± 1.07) compared to the normal-folate group (2.88 ± 1.13, p = 0.013). High ferritin levels were associated with more DOA (1.79 ± 0.89) compared to the normal-ferritin group (1.51 ± 0.67, p = 0.034). Moderate anemia was significantly associated with decreased FC (p = 0.023) and increased DOA (p = 0.030). Abnormal hemoglobin (Hgb), ferritin, and folate statuses did not exhibit significant differences in survival analysis.

Conclusions: The findings reveal that folate, ferritin, and Hgb levels are significantly associated with apheresis outcomes, offering guidance for optimizing stem cell mobilization in patients with MM.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

铁蛋白和叶酸在多发性骨髓瘤自体干细胞移植干细胞收集中的作用。

背景：自体干细胞移植（ASCT）是符合条件的多发性骨髓瘤（MM）患者的标准治疗。然而，ASCT的成功在很大程度上取决于有效的动员；因此，对可能影响动员的因素进行彻底分析是必不可少的。方法：本研究采用单中心、回顾性图表回顾的方法，对2016年至2023年接受首次或第二次自体骨髓移植的292例成年MM患者进行研究。从电子病历（EMR）中检索患者的人口统计资料、采集前评估访问时的血清实验室值、采血第一天的干细胞捕获总量（TC）（CD34/kg × 106）和采血总天数（DOA）。结果：叶酸水平高的人的DOA（1.43±0.61）低于叶酸水平正常的人（1.68±0.82,p = 0.013）。高叶酸组的FC（3.26±1.07）高于正常叶酸组（2.88±1.13,p = 0.013）。与铁蛋白正常组（1.51±0.67,p = 0.034）相比，高铁蛋白水平组的DOA（1.79±0.89）更高。中度贫血与FC降低（p = 0.023）和DOA升高（p = 0.030）显著相关。异常血红蛋白（Hgb）、铁蛋白和叶酸状态在生存分析中没有显着差异。结论：研究结果显示叶酸、铁蛋白和血红蛋白水平与分离结果显著相关，为优化MM患者的干细胞动员提供了指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊