Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques.

IF 2.4 Q2 INFECTIOUS DISEASES Infectious Disease Reports Pub Date : 2025-02-06 DOI:10.3390/idr17010012

Julien A Clain, Morgane Picard, Henintsoa Rabezanahary, Sonia André, Steven Boutrais, Ella Goma Matsetse, Juliette Dewatines, Quentin Dueymes, Elise Thiboutot, Gina Racine, Calaiselvy Soundaramourty, Fabrizio Mammano, Pierre Corbeau, Ouafa Zghidi-Abouzid, Jérôme Estaquier

{"title":"Immune Alterations and Viral Reservoir Atlas in SIV-Infected Chinese Rhesus Macaques.","authors":"Julien A Clain, Morgane Picard, Henintsoa Rabezanahary, Sonia André, Steven Boutrais, Ella Goma Matsetse, Juliette Dewatines, Quentin Dueymes, Elise Thiboutot, Gina Racine, Calaiselvy Soundaramourty, Fabrizio Mammano, Pierre Corbeau, Ouafa Zghidi-Abouzid, Jérôme Estaquier","doi":"10.3390/idr17010012","DOIUrl":null,"url":null,"abstract":"Background/objectives: Over the last decades, our projects have been dedicated to clarifying immunopathological and virological events associated with Human Immunodeficiency Virus (HIV) infection.Methods: By using non-human primate models of pathogenic and non-pathogenic lentiviral infections, we aimed at identifying the cells and tissues in which the virus persists, despite antiretroviral therapy (ART). Indeed, the eradication of viral reservoirs is a major challenge for HIV cure.Results: We present a series of results performed in rhesus macaques of Chinese origin deciphering the virological and immunological events associated with ART that can be of interest for people living with HIV.Conclusions: This model could be of interest for understanding in whole body the clinical alteration that persist despite ART.","PeriodicalId":13579,"journal":{"name":"Infectious Disease Reports","volume":"17 1","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11855486/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Infectious Disease Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/idr17010012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Background/objectives: Over the last decades, our projects have been dedicated to clarifying immunopathological and virological events associated with Human Immunodeficiency Virus (HIV) infection.

Methods: By using non-human primate models of pathogenic and non-pathogenic lentiviral infections, we aimed at identifying the cells and tissues in which the virus persists, despite antiretroviral therapy (ART). Indeed, the eradication of viral reservoirs is a major challenge for HIV cure.

Results: We present a series of results performed in rhesus macaques of Chinese origin deciphering the virological and immunological events associated with ART that can be of interest for people living with HIV.

Conclusions: This model could be of interest for understanding in whole body the clinical alteration that persist despite ART.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

siv感染中国恒河猴的免疫改变和病毒库图谱。

背景/目的：在过去的几十年里，我们的项目一直致力于澄清与人类免疫缺陷病毒（HIV）感染相关的免疫病理和病毒学事件。方法：通过使用致病性和非致病性慢病毒感染的非人灵长类动物模型，我们旨在鉴定尽管抗逆转录病毒治疗（ART），病毒仍然存在的细胞和组织。事实上，根除病毒宿主是治愈艾滋病的主要挑战。结果：我们提出了一系列在中国恒河猴身上进行的研究结果，揭示了与抗逆转录病毒治疗相关的病毒学和免疫学事件，这些事件可能对艾滋病毒感染者感兴趣。结论：该模型有助于理解尽管ART仍持续存在的全身临床改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊