In Vitro Bacterial Growth on Titanium Surfaces Treated with Nanosized Hydroxyapatite.

IF 5.2 3区医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2025-02-16 DOI:10.3390/jfb16020066

Maria Holmström, Sonia Esko, Karin Danielsson, Per Kjellin

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Abstract

Bacterial growth on implant surfaces poses a significant obstacle to the long-term success of dental and orthopedic implants. There is a need for implants that promote osseointegration while at the same time decreasing or preventing bacterial growth. In this study, the existing methods for the measurement of bacterial biofilms were adapted so that they were suitable for measuring the bacterial growth on implant surfaces. Two different strains of bacteria, Pseudomonas aeruginosa and Staphylococcus epidermidis, were used, and the in vitro effect of bacterial growth on titanium surfaces coated with an ultrathin (20-40 nm thick) layer of nanosized hydroxyapatite (nHA) was investigated. After 2 h of biofilm growth, there was a 33% reduction in both S. epidermidis and P. aeruginosa bacteria on nHA compared to Ti. For a more mature 24 h biofilm, there was a 46% reduction in S. epidermidis and a 43% reduction in P. aeruginosa on nHA compared to Ti. This shows that coating nHA onto implants could be of benefit in reducing implant-related infections.

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细菌在纳米羟基磷灰石处理过的钛表面上的体外生长。

细菌在种植体表面的生长对牙科和骨科种植体的长期成功造成了重大障碍。需要种植体促进骨整合，同时减少或防止细菌生长。在本研究中，对现有的测量细菌生物膜的方法进行了调整，使其适合于测量种植体表面的细菌生长。以铜绿假单胞菌（Pseudomonas aeruginosa）和表皮葡萄球菌（Staphylococcus epidermidis）两种不同的细菌为研究对象，研究了细菌在钛表面涂覆超薄（20 ~ 40 nm厚）纳米羟基磷灰石（nHA）的体外生长效果。生物膜生长2 h后，与Ti相比，nHA上表皮葡萄球菌和铜绿假单胞菌的数量均减少33%。对于更成熟的24 h生物膜，与Ti相比，nHA上的表皮葡萄球菌减少了46%，铜绿假单胞菌减少了43%。这表明在种植体上涂覆nHA可以减少种植体相关感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Functional Biomaterials Engineering-Biomedical Engineering

CiteScore

4.60

自引率

4.20%

发文量

226

审稿时长

11 weeks

期刊介绍： Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.