Discovery of MK8383s with Antifungal Activity from Mangrove Endophytic Fungi Medicopsis sp. SCSIO 40440 Against Fusarium Wilt of Banana.

IF 5.4 2区医学 Q1 CHEMISTRY, MEDICINAL Marine Drugs Pub Date : 2025-02-18 DOI:10.3390/md23020088

Tianyu Zhou, Yulei Qiao, Lu Wang, Zifeng Li, Haibo Zhang, Liping Zhang, Shengrong Liao, Minhui Li, Changsheng Zhang, Wenjun Zhang

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Abstract

Fusarium wilt of banana (FWB), caused by Fusarium oxysporum f. sp. cubense (Foc) tropical race 4 (TR4), poses a severe threat to the global banana industry. The screening of endophytic fungi from the mangrove plant led to the identification of Medicopsis sp. SCSIO 40440, which exhibited potent antifungal activity against Fusarium. The further fraction of the extract yielded ten compounds, including MK8383 (1) and nine new analogues, MK8383s B-J (2-10). The structures of 1-10 were elucidated using extensive spectroscopic data and single-crystal X-ray diffraction analysis. In vitro antifungal assays revealed that 1 showed strongly antifungal activities against Foc TR4, with an EC₅₀ of 0.28 μg/mL, surpassing nystatin and hygromycin B (32 and 16 μg/mL, respectively). Pot experiments showed that 1 or spores of SCSIO 40440 could significantly reduce the virulence of Foc TR4 on Cavendish banana.

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红树内生真菌Medicopsis sp. SCSIO 40440抗香蕉枯萎病活性的mk8333s的发现

香蕉枯萎病（Fusarium wilt of banana， FWB）是由Fusarium oxysporum f. sp. cubense （Foc）热带小种4 （TR4）引起的香蕉枯萎病，对全球香蕉产业构成严重威胁。通过对红树植物内生真菌的筛选，鉴定出对镰刀菌具有较强抗真菌活性的Medicopsis sp. SCSIO 40440。进一步提取得到10个化合物，包括MK8383(1)和9个新的类似物mk833s B-J（2-10）。利用广泛的光谱数据和单晶x射线衍射分析对1-10的结构进行了阐明。体外抑菌实验表明，1对Foc TR4具有较强的抑菌活性，EC50为0.28 μg/mL，优于制霉菌素和潮霉素B（分别为32和16 μg/mL）。盆栽试验表明，SCSIO 40440 1株或孢子可显著降低Foc TR4对卡文迪什香蕉的毒力。

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.