{"title":"The Molecular Mechanisms of the FLASH Effect in Radiobiology","authors":"S. I. Glukhov, E. A. Kuznetsova","doi":"10.1134/S0006350924700830","DOIUrl":null,"url":null,"abstract":"<div><p>The use of ionizing radiation at an ultra-high dose rate (≥40 Gy/s), which is called FLASH irradiation, contributes to the preservation of healthy tissues with a level of tumor control comparable to that of irradiation at a standard dose rate. This review summarizes the current knowledge obtained in studies of irradiation of tumor and normal cell lines and animals, including tumor carriers, in conventional and FLASH modes. For comparison, data on FLASH irradiation with photons, electrons, and protons, as well as ions of helium and carbon, are also provided. The biophysical, molecular biological, and immunological aspects of FLASH exposure necessary for understanding radiation-induced processes in cells and tissues in order to improve tumor radiotherapy are discussed.</p></div>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"69 4","pages":"749 - 767"},"PeriodicalIF":4.0330,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1134/S0006350924700830","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
The use of ionizing radiation at an ultra-high dose rate (≥40 Gy/s), which is called FLASH irradiation, contributes to the preservation of healthy tissues with a level of tumor control comparable to that of irradiation at a standard dose rate. This review summarizes the current knowledge obtained in studies of irradiation of tumor and normal cell lines and animals, including tumor carriers, in conventional and FLASH modes. For comparison, data on FLASH irradiation with photons, electrons, and protons, as well as ions of helium and carbon, are also provided. The biophysical, molecular biological, and immunological aspects of FLASH exposure necessary for understanding radiation-induced processes in cells and tissues in order to improve tumor radiotherapy are discussed.
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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