Penetration of Polyphenols through Acetic Acid Damaged Skin

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2025-02-26 DOI:10.1134/S0006350924700866
V. S. Shubina, Yu. V. Shatalin
{"title":"Penetration of Polyphenols through Acetic Acid Damaged Skin","authors":"V. S. Shubina,&nbsp;Yu. V. Shatalin","doi":"10.1134/S0006350924700866","DOIUrl":null,"url":null,"abstract":"<div><p>Previously, we showed that taxifolin derivatives, taxifolin pentaglutarate and a conjugate of taxifolin with glyoxylic acid, improve the mechanical properties of collagen-based materials. In the process of degradation of such materials, biologically active polyphenols are released into the surrounding medium. Two approaches were used to assess the penetration of polyphenols through damaged skin. In the case of taxifolin pentaglutarate and taxifolin (used for comparison), a fluorescent label was introduced into the structure of the polyphenol. In the case of the conjugate, a fluorescent analogue was obtained. It has been shown that the application of polyphenolic compounds on the damaged skin leads to the formation of a fluorescent layer on its surface. Fluorescent derivatives of taxifolin and taxifolin pentaglutarate have been found to accumulate in hair follicles. In the case of taxifolin, fluorescence was observed in deeper layers of the dermis than in the case of taxifolin pentaglutarate, indicating better penetration of taxifolin. The fluorescent analog accumulated in the appendages of the skin to a lesser extent than other compounds. Thus, the data we obtained indicate the accumulation of polyphenols in the hair follicles, from which they can gradually be released into the surrounding tissue. In general, the results we obtained indicate that biologically active polyphenols are able to exert a prolonged effect when applied topically. This may be important in the treatment of burns, in particular in the treatment of second-degree burns, in which many skin derivatives remain intact.</p></div>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"69 4","pages":"784 - 791"},"PeriodicalIF":4.0330,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1134/S0006350924700866","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0

Abstract

Previously, we showed that taxifolin derivatives, taxifolin pentaglutarate and a conjugate of taxifolin with glyoxylic acid, improve the mechanical properties of collagen-based materials. In the process of degradation of such materials, biologically active polyphenols are released into the surrounding medium. Two approaches were used to assess the penetration of polyphenols through damaged skin. In the case of taxifolin pentaglutarate and taxifolin (used for comparison), a fluorescent label was introduced into the structure of the polyphenol. In the case of the conjugate, a fluorescent analogue was obtained. It has been shown that the application of polyphenolic compounds on the damaged skin leads to the formation of a fluorescent layer on its surface. Fluorescent derivatives of taxifolin and taxifolin pentaglutarate have been found to accumulate in hair follicles. In the case of taxifolin, fluorescence was observed in deeper layers of the dermis than in the case of taxifolin pentaglutarate, indicating better penetration of taxifolin. The fluorescent analog accumulated in the appendages of the skin to a lesser extent than other compounds. Thus, the data we obtained indicate the accumulation of polyphenols in the hair follicles, from which they can gradually be released into the surrounding tissue. In general, the results we obtained indicate that biologically active polyphenols are able to exert a prolonged effect when applied topically. This may be important in the treatment of burns, in particular in the treatment of second-degree burns, in which many skin derivatives remain intact.

Abstract Image

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
求助全文
约1分钟内获得全文 去求助
来源期刊
Biophysics
Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍: Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
期刊最新文献
Typical Pathological Process in Glutamate Neurotoxicity: The Role of Reactive Nitrogen and Oxygen Species A Study of the Peculiarities of the Formation of Behavioral Skills in Rats in a Three-Way Maze Mechanisms of the Formation and Function of Dinitrosyl Iron Complexes as a “Working Form” of Nitric Oxide in Living Organisms Models of Flowering Gene Networks and their Adaptation for the Analysis of Vernalization Mechanisms in Legumes The Behavior of a Population of Protozoan Microorganisms under Electromagnetic Radiation from Cell Phones
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1