Noncontact Atomic Force Microscopy for Studies of Biomolecules in Liquids

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2025-02-26 DOI:10.1134/S0006350924700702
T. Mamedov, A. Shvirst, M. V. Fedotova, G. N. Chuev
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Abstract—Noncontact atomic force microscopy, a type of scanning probe microscopy, has been actively used in the last 2 decades to study hydrated biomolecules. In particular, as the analysis of modern literature shows, it is very promising in the study of adsorbed biomacromolecules and biomacromolecular complexes at the interface or on the surface of membranes. This mini-review describes the basics of this method and its application to biomolecules; the requirements for the method and the possibilities of its extension due to additional processing of the experimental data obtained using theoretical analysis, molecular modeling and machine learning are discussed.

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来源期刊
Biophysics
Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍: Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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