The Degree of Specificity of Synaptic Contacts during Neurotransplantation

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology Biophysics Pub Date : 2025-02-26 DOI:10.1134/S0006350924700738
Z. N. Zhuravleva
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引用次数: 0

Abstract

Transplantation of immature nerve tissue is a promising biotechnological approach to repair damaged brain tissue. The success of transplantation therapy depends on a genetic program for the differentiation of donor neuronal precursors and the accuracy of neural connections both in the neurotransplants themselves and in the recipient’s brain. The degree of specificity of synaptic contacts during transplantation of the hippocampal formation into the rat neocortex was studied. Using the method of electron microscopy, it was shown that in the transplants themselves mainly specific forms of synapses were differentiated, which were topographically correctly located on the soma-dendritic surface of neurons. The axons of the transplanted neurons growing into the recipient’s brain formed synaptic contacts with normally unusual neurons. During the formation of nonspecific axonal connections, they modified the composition and distribution of neurotransmitter vesicles in presynaptic terminals, as well as inducing structural and chemical reorganization in postsynaptic dendrites.

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来源期刊
Biophysics
Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍: Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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