{"title":"Paraptosis and Other Types of Nonapoptotic Regulated Cell Death","authors":"M. E. Solovieva, Yu. V. Shatalin, V. S. Akatov","doi":"10.1134/S0006350924700763","DOIUrl":null,"url":null,"abstract":"<div><p>This review is devoted to modern concepts of paraptosis as one of the types of regulated cell death, in comparison with other types of cell death. Paraptosis is a form of cell death caused by stress of the endoplasmic reticulum (ER), accompanied by the accumulation of damaged or incorrectly folded proteins in it, extensive nonautophagic vacuolation of the cisterns of the endoplasmic reticulum and, in some cases, mitochondria, with subsequent damage to the mitochondria and cytoskeleton and cell death. Knowledge about the molecular mechanisms of paraptosis is of interest for the treatment of cancer diseases resistant to apoptosis-inducing agents.</p></div>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"69 4","pages":"674 - 691"},"PeriodicalIF":4.0330,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1134/S0006350924700763","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
This review is devoted to modern concepts of paraptosis as one of the types of regulated cell death, in comparison with other types of cell death. Paraptosis is a form of cell death caused by stress of the endoplasmic reticulum (ER), accompanied by the accumulation of damaged or incorrectly folded proteins in it, extensive nonautophagic vacuolation of the cisterns of the endoplasmic reticulum and, in some cases, mitochondria, with subsequent damage to the mitochondria and cytoskeleton and cell death. Knowledge about the molecular mechanisms of paraptosis is of interest for the treatment of cancer diseases resistant to apoptosis-inducing agents.
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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