The Prognostic Value of Tumor-Associated Neutrophils in Colorectal Cancer: A Systematic Review and Meta-Analysis

IF 3.1 2区医学 Q2 ONCOLOGY Cancer Medicine Pub Date : 2025-02-27 DOI:10.1002/cam4.70614

Mengyuan Jiang, Rui Zhang, Min Huang, Jing Yang, Qianqian Liu, Ziru Zhao, Ya Ma, Hongfan Zhao, Min Zhang

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Abstract

Background

Tumor-associated neutrophils (TANs) are important components of the colorectal cancer (CRC) microenvironment. However, their role in CRC remains controversial. This study aimed to assess the prognostic value of TANs in patients with CRC.

Methods

We searched the PubMed, EMBASE, and Cochrane Library databases for eligible studies published until January 9, 2023. The pooled hazard ratios (HRs) and odds ratios (ORs) with their 95% confidence intervals (95% CI) were calculated with a random-effects model to assess survival outcomes and clinicopathological features. Subgroup analyses were further conducted to identify potential sources of heterogeneity. Funnel plots and Egger's test were used to measure publication bias.

Results

A total of 19 studies with 7721 patients were included in this meta-analysis. The pooled analysis indicated that high peritumoral TAN infiltration in CRC tissue was significantly associated with favorable cancer-specific survival (HR = 0.57; 95% CI: 0.38–0.86; p = 0.007), but not with overall survival or disease-free survival. No association between high intratumoral or unclear compartment TAN infiltration and CRC prognosis was found. Subgroup analyses showed that the association between TANs and the prognosis of CRC patients differed according to antibody types, tumor stage, quantitative methods, and follow-up time. High intratumoral TAN infiltration was significantly associated with histology type, whereas high TAN infiltration in an unclear compartment was significantly associated with gender, tumor location, and the primary tumor site.

Conclusions

High TAN infiltration, especially in the peritumoral compartment, could be a potential prognostic marker in CRC. More high-quality studies are required to explore its specific prognostic value in CRC.

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肿瘤相关中性粒细胞在结直肠癌中的预后价值：系统综述和荟萃分析

肿瘤相关中性粒细胞（TANs）是结直肠癌（CRC）微环境的重要组成部分。然而，它们在CRC中的作用仍然存在争议。本研究旨在评估TANs在结直肠癌患者中的预后价值。方法检索PubMed、EMBASE和Cochrane图书馆数据库，查找2023年1月9日前发表的符合条件的研究。采用随机效应模型计算合并风险比（hr）和优势比（ORs）及其95%可信区间（95% CI），以评估生存结局和临床病理特征。进一步进行亚组分析以确定潜在的异质性来源。采用漏斗图和Egger检验来测量发表偏倚。结果本荟萃分析共纳入19项研究，共7721例患者。合并分析表明，结直肠癌组织中高瘤周TAN浸润与良好的癌症特异性生存显著相关(HR = 0.57；95% ci: 0.38-0.86；P = 0.007)，但与总生存期或无病生存期无关。瘤内高浸润或腔室不清的TAN与结直肠癌预后无关联。亚组分析显示，TANs与结直肠癌患者预后的相关性因抗体类型、肿瘤分期、定量方法和随访时间的不同而不同。瘤内高TAN浸润与组织学类型显著相关，而不明确腔室的高TAN浸润与性别、肿瘤位置和原发肿瘤部位显著相关。结论高TAN浸润，尤其是瘤周腔室浸润，可能是结直肠癌的潜在预后标志。需要更多高质量的研究来探讨其在结直肠癌中的具体预后价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.