Mitochondrial Quality Control and Melatonin: A Strategy Against Myocardial Injury

IF 2.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Biochemical and Molecular Toxicology Pub Date : 2025-02-26 DOI:10.1002/jbt.70194

Nima Ghavamikia, Faranak Mehrnoosh, Farshad Zare, Payam Ali-khiavi, Ali Sinehsepehr, Yasaman Ghodsi Boushehri, Milad Vahedinezhad, Elham Abdollahi, Ahmed Hjazi, Siamak Aminnezhad, Hossein Saffarfar, Sina Hamzehzadeh, Mehrdad Nourizadeh, Sepideh KarkonShayan

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Abstract

Melatonin exhibits various biological functions, including regulation of circadian and endocrine rhythms, anti-inflammatory, and antioxidant effects. Aging and damaged mitochondria are major sources of oxidative stress (OS), and mitochondrial quality control (MQC) is crucial for maintaining normal mitochondrial function. Myocardial ischemia-reperfusion injury is a major complication that can arise during reperfusion therapy for coronary heart disease. However, effective intervention strategies are currently lacking. Mitochondrial dysfunction and OS are considered central mechanisms of myocardial reperfusion injury, with mitochondrial-targeted interventions being a potential treatment direction. Recent studies have shown that melatonin improves mitochondrial structure and function through multiple pathways. This review discusses the mechanisms by which melatonin ameliorates myocardial ischemia-reperfusion injury, focusing on MQC, and explores its potential applications in the prevention and treatment of myocardial ischemia-reperfusion injury.

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线粒体质量控制和褪黑素：对抗心肌损伤的策略

褪黑素具有多种生物学功能，包括调节昼夜节律和内分泌节律、抗炎和抗氧化作用。老化和线粒体损伤是氧化应激（OS）的主要来源，而线粒体质量控制（MQC）对于维持线粒体正常功能至关重要。心肌缺血再灌注损伤是冠心病再灌注治疗的主要并发症。然而，目前缺乏有效的干预策略。线粒体功能障碍和OS被认为是心肌再灌注损伤的主要机制，线粒体靶向干预是一个潜在的治疗方向。最近的研究表明，褪黑素通过多种途径改善线粒体结构和功能。本文就褪黑素改善心肌缺血-再灌注损伤的机制进行综述，重点探讨其在心肌缺血-再灌注损伤预防和治疗中的潜在应用。

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来源期刊

Journal of Biochemical and Molecular Toxicology 生物-毒理学

CiteScore

5.80

自引率

2.80%

发文量

277

审稿时长

6-12 weeks

期刊介绍： The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents. The scope includes effects on the organism at all stages of development, on organ systems, tissues, and cells as well as on enzymes, receptors, hormones, and genes. The biochemical and molecular aspects of uptake, transport, storage, excretion, lactivation and detoxication of drugs, agricultural, industrial and environmental chemicals, natural products and food additives are all subjects suitable for publication. Of particular interest are aspects of molecular biology related to biochemical toxicology. These include studies of the expression of genes related to detoxication and activation enzymes, toxicants with modes of action involving effects on nucleic acids, gene expression and protein synthesis, and the toxicity of products derived from biotechnology.