Molecular Insights in Endometrial Stromal Sarcomas: Exploring New Targets for Novel Therapeutic Approaches.

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomolecules Pub Date : 2025-02-11 DOI:10.3390/biom15020265

Alice Costa, Annalisa Astolfi, Livia Gozzellino, Margherita Nannini, Gianandrea Pasquinelli, Maria Abbondanza Pantaleo

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Abstract

Uterine mesenchymal tumors (UMTs) are the second most common type of tumors within the uterus corpus after endometrial carcinomas. Among the UMTs, smooth muscle neoplasms are the most common subtype, followed by endometrial stromal sarcoma (ESS). ESSs are uncommon malignancies characterized by molecular heterogeneity and an aggressive behavior. Their management poses significant challenges, particularly for high-grade subtypes. Surgery is the primary intervention for localized disease, while the role of adjuvant therapies, including radiation and chemotherapy, must be better investigated. Hormonal therapy has shown efficacy in low-grade cases but limited success in high-grade tumors. Recent advancements in molecular profiling have revealed potential targets, offering promise for personalized treatments. However, novel therapeutic strategies are urgently needed to improve patient outcomes, particularly for advanced and recurrent disease. This review offers a perspective on the possible novel therapeutic approaches based on the most recent molecular analyses performed on endometrial stromal sarcomas.

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子宫内膜间质肉瘤的分子洞察：探索新的治疗方法的新靶点。

子宫间质肿瘤（UMTs）是子宫内第二常见的肿瘤类型，仅次于子宫内膜癌。在umt中，平滑肌肿瘤是最常见的亚型，其次是子宫内膜间质肉瘤（ESS）。ESSs是一种罕见的恶性肿瘤，具有分子异质性和侵袭性。它们的管理面临着重大挑战，特别是对于高级亚型。手术是局部疾病的主要干预措施，而辅助治疗的作用，包括放疗和化疗，必须更好地研究。激素治疗对低级别肿瘤有疗效，但对高级别肿瘤疗效有限。分子谱分析的最新进展揭示了潜在的靶点，为个性化治疗提供了希望。然而，迫切需要新的治疗策略来改善患者的预后，特别是对于晚期和复发性疾病。本文基于最近对子宫内膜间质肉瘤进行的分子分析，对可能的新治疗方法进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.