Ultra-Processed Foods and Type 2 Diabetes Mellitus: What Is the Evidence So Far?

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomolecules Pub Date : 2025-02-19 DOI:10.3390/biom15020307
Natalia G Vallianou, Angelos Evangelopoulos, Ilektra Tzivaki, Stavroula Daskalopoulou, Andreas Adamou, Georgia Chrysi Michalaki Zafeiri, Irene Karampela, Maria Dalamaga, Dimitris Kounatidis
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Abstract

Ultra-processed foods (UPFs) are foods that have undergone extensive industrial processing with the addition of various substances in order to make them more tasty, eye-catching, and easy to consume. UPFs are usually rich in sugars, salt, and saturated fat, whereas they lack essential nutrients. The aim of this review is to elaborate upon the current evidence associating overconsumption of UPFs with the development of type 2 diabetes mellitus (T2DM). We will discuss data interconnecting UPFs and T2DM risk and will further describe specific ingredients that have been suggested to increase this risk. In addition, we will thoroughly explain how additives, such as emulsifiers or sweeteners, or other compounds formed during manufacturing, such as acrylamide and acrolein, and during packaging, such as bisphenol-A, are proposed to be implicated in the pathogenesis of insulin resistance and T2DM.

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超加工食品与 2 型糖尿病:目前有哪些证据?
超加工食品(upf)是经过广泛的工业加工,添加各种物质,使其更美味,更引人注目,更容易食用的食品。upf通常含有丰富的糖、盐和饱和脂肪,但缺乏必需的营养素。这篇综述的目的是详细阐述目前的证据表明过度食用upf与2型糖尿病(T2DM)的发展有关。我们将讨论upf和T2DM风险之间的关联数据,并将进一步描述被认为会增加这种风险的具体成分。此外,我们将彻底解释添加剂,如乳化剂或甜味剂,或在生产过程中形成的其他化合物,如丙烯酰胺和丙烯醛,以及在包装过程中形成的双酚a,如何被认为与胰岛素抵抗和2型糖尿病的发病机制有关。
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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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