Organocyclophosphazenes and Materials Based on Them for Pharmaceuticals and Biomedicine.

Abstract

This review examines representatives of organocyclophosphazenes that can act against tumor cells of the ovaries, prostate gland, mammary gland, and colon, etc., and have antimicrobial action against mycobacteria M. tuberculosis, Gram-positive bacteria B. cereus, Gram-negative bacteria K. pneumaniae, fungi of the genus Candida, and other microorganisms. Cyclomatric phosphazenes can be used as carriers of physiologically active substances and in the field of detection, as well as gels for wound surgery and drug delivery platforms. In gels, cyclophosphazenes are used as cross-linking agents. Cyclophosphazenes containing multiple bonds in organic radicals are proposed to be used in dentistry as additives to basic dental compositions. Particular attention in the review is paid to the cytotoxic and antimicrobial action of materials containing cyclophosphazenes and their advantages over commercial physiologically active substances. The review presents the prospects for the practical application of cyclophosphazenes containing various functional groups (chalcone, anthraquinone, pyrrolidine, morpholine, and ferrocene, etc.) in pharmaceuticals. The review may be of interest to researchers working in the field of organoelement chemistry, medicine, and pharmacy.