Predictive Value of Hyperintense Acute Reperfusion Marker in Transient Ischemic Attacks: Stroke Recurrence and TOAST Classification.

IF 2.8 3区医学 Q3 NEUROSCIENCES Brain Sciences Pub Date : 2025-02-10 DOI:10.3390/brainsci15020170

Sang-Hoon Han, Kyu-Sun Yum

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Abstract

Background: Transient ischemic attack (TIA) is a recognized precursor of stroke that also indicates a high risk of recurrence. The Hyperintense Acute Reperfusion Marker (HARM), which is linked to blood-brain barrier disruption, may serve as a novel imaging biomarker for TIA.

Methods: A retrospective cohort study of 715 patients with TIA evaluated the predictive value of HARM for stroke recurrence and its association with TOAST subtype. Imaging findings, including those of diffusion-weighted imaging, were analyzed using logistic regression.

Results: HARM-positive patients had significantly higher recurrence rates at 3 months (20.9%; odds ratio [OR] = 5.3) and 1 year (30.2%; OR = 5.8) compared to HARM-negative patients, relative to other imaging markers (p < 0.001). HARM was significantly associated with the cardioembolic stroke (p < 0.001).

Conclusions: HARM is a promising imaging biomarker for predicting stroke recurrence and etiology in patients experiencing TIA. Incorporating HARM into clinical frameworks may enhance diagnostic and prognostic accuracy.

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高强度急性再灌注标志物在短暂性脑缺血发作中的预测价值：卒中复发和TOAST分类。

背景：短暂性脑缺血发作（TIA）是公认的卒中前兆，也预示着复发的高风险。高强度急性再灌注标志物（HARM）与血脑屏障破坏有关，可能作为TIA的一种新的成像生物标志物。方法：对715例TIA患者进行回顾性队列研究，评估HARM对卒中复发的预测价值及其与TOAST亚型的关系。影像学结果，包括弥散加权影像学结果，采用logistic回归分析。结果：harm阳性患者3个月复发率明显高于对照组(20.9%；优势比[OR] = 5.3)和1年(30.2%；OR = 5.8)，与其他影像学指标相比（p < 0.001）。HARM与心栓塞性卒中显著相关（p < 0.001）。结论：HARM是一种很有前景的成像生物标志物，可用于预测TIA患者的卒中复发和病因。将HARM纳入临床框架可以提高诊断和预后的准确性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Sciences Neuroscience-General Neuroscience

CiteScore

4.80

自引率

9.10%

发文量

1472

审稿时长

18.71 days

期刊介绍： Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.