{"title":"Analysis of the global burden of ovarian cancer in adolescents.","authors":"Mengting Che, Rutie Yin","doi":"10.1016/j.ijgc.2024.101620","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Ovarian cancer is the most prevalent gynecologic malignancy in adolescents, predominantly characterized by non-epithelial cancer. We aim to analyze the epidemiological characteristics of ovarian cancer in various regions and countries within this specific population.</p><p><strong>Methods: </strong>This is a cross-sectional study using data from the Global Burden of Disease 2021 study, which included adolescents with ovarian cancer aged 15 to 24 years in 204 countries and territories from 1990 to 2021. We retrieved data on incidence, mortality, and disability-adjusted life years, and calculated estimated annual percentage changes to assess the temporal trends. In addition, we explored the relationship between the disease burden and the Socio-demographic Index and performed decomposition analysis.</p><p><strong>Results: </strong>Globally, in 2021, the incidence, mortality, and disability-adjusted life years for ovarian cancer among adolescents were reported as 11,087 (95% CI 8893-12,899), 1573 (95% CI 1249-1832), and 115,075 (95% CI 91,622-134,050), respectively, with all corresponding age-standardized rates showing increasing trends from 1990 to 2021. Among the 5 Socio-demographic Index regions, the middle Socio-demographic Index region exhibited the highest age-standardized incidence rate (2.27, 95% CI 1.75-2.66), while the region with the highest age-standardized mortality rate and the most significant increase in disease burden was the low-middle region. Furthermore, out of 21 geographical regions, Southeast Asia reported the highest age-standardized incidence rate (4.48, 95% CI 3.00-6.12), while Central Latin America had the highest age-standardized mortality rate (0.42, 95% CI 0.36-0.49). Andean Latin America had the greatest increase in disease burden, while Australasia had the greatest decrease.</p><p><strong>Conclusions: </strong>The disease burden of ovarian cancer among adolescents continues to rise globally, particularly in regions and countries with moderate to low economic development. Enhancing the equitable allocation of health care resources to facilitate early diagnosis and treatment is essential for future treatment and research strategies.</p>","PeriodicalId":14097,"journal":{"name":"International Journal of Gynecological Cancer","volume":" ","pages":"101620"},"PeriodicalIF":4.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Gynecological Cancer","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.ijgc.2024.101620","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/8 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: Ovarian cancer is the most prevalent gynecologic malignancy in adolescents, predominantly characterized by non-epithelial cancer. We aim to analyze the epidemiological characteristics of ovarian cancer in various regions and countries within this specific population.
Methods: This is a cross-sectional study using data from the Global Burden of Disease 2021 study, which included adolescents with ovarian cancer aged 15 to 24 years in 204 countries and territories from 1990 to 2021. We retrieved data on incidence, mortality, and disability-adjusted life years, and calculated estimated annual percentage changes to assess the temporal trends. In addition, we explored the relationship between the disease burden and the Socio-demographic Index and performed decomposition analysis.
Results: Globally, in 2021, the incidence, mortality, and disability-adjusted life years for ovarian cancer among adolescents were reported as 11,087 (95% CI 8893-12,899), 1573 (95% CI 1249-1832), and 115,075 (95% CI 91,622-134,050), respectively, with all corresponding age-standardized rates showing increasing trends from 1990 to 2021. Among the 5 Socio-demographic Index regions, the middle Socio-demographic Index region exhibited the highest age-standardized incidence rate (2.27, 95% CI 1.75-2.66), while the region with the highest age-standardized mortality rate and the most significant increase in disease burden was the low-middle region. Furthermore, out of 21 geographical regions, Southeast Asia reported the highest age-standardized incidence rate (4.48, 95% CI 3.00-6.12), while Central Latin America had the highest age-standardized mortality rate (0.42, 95% CI 0.36-0.49). Andean Latin America had the greatest increase in disease burden, while Australasia had the greatest decrease.
Conclusions: The disease burden of ovarian cancer among adolescents continues to rise globally, particularly in regions and countries with moderate to low economic development. Enhancing the equitable allocation of health care resources to facilitate early diagnosis and treatment is essential for future treatment and research strategies.
目的：卵巢癌是青少年最常见的妇科恶性肿瘤，以非上皮性肿瘤为主要特征。我们的目的是分析不同地区和国家在这一特定人群中卵巢癌的流行病学特征。方法：这是一项横断面研究，使用2021年全球疾病负担研究的数据，其中包括1990年至2021年期间204个国家和地区15至24岁的卵巢癌青少年。我们检索了有关发病率、死亡率和残疾调整生命年的数据，并计算了估计的年百分比变化以评估时间趋势。此外，我们探讨了疾病负担与社会人口指数之间的关系，并进行了分解分析。结果：在全球范围内，2021年，青少年卵巢癌的发病率、死亡率和残疾调整生命年分别为11087年（95% CI 8893-12,899）、1573年（95% CI 1249-1832）和115075年（95% CI 91,622-134,050），所有相应的年龄标准化率从1990年到2021年显示出增加趋势。5个社会人口指数区中，年龄标准化发病率最高（2.27,95% CI 1.75 ~ 2.66），而年龄标准化死亡率最高、疾病负担增加最显著的地区为中低地区。此外，在21个地理区域中，东南亚报告的年龄标准化发病率最高（4.48,95% CI 3.00-6.12），而中拉丁美洲的年龄标准化死亡率最高（0.42,95% CI 0.36-0.49）。安第斯拉丁美洲的疾病负担增加最多，而大洋洲的疾病负担减少最多。结论：全球青少年卵巢癌疾病负担持续上升，特别是在经济发展中至低的地区和国家。加强卫生保健资源的公平分配，以促进早期诊断和治疗，对今后的治疗和研究战略至关重要。
期刊介绍：
The International Journal of Gynecological Cancer, the official journal of the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology, is the primary educational and informational publication for topics relevant to detection, prevention, diagnosis, and treatment of gynecologic malignancies. IJGC emphasizes a multidisciplinary approach, and includes original research, reviews, and video articles. The audience consists of gynecologists, medical oncologists, radiation oncologists, radiologists, pathologists, and research scientists with a special interest in gynecological oncology.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
