Sleep Induction in Pediatric EEG Recordings: Chloral Hydrate Versus Melatonin and Hydoxyzine.

Abstract

Purpose: Electroencephalography (EEG) recording in pediatric patients is difficult because of patient compliance, and children who are unsuitable for behavioral training usually require sedation for EEG recordings. The aim of this study was to examine the effects of agents commonly used in daily practice for sleep induction on sleep transition, sleep architecture, and frequency of movement artifacts on EEG recordings.

Methods: A retrospective analysis was made of the demographic data and sleep EEG recordings of patients who underwent sleep EEG because of suspected seizure between 2021 and 2022. The study included patients aged 4 to 18 years, and patients with a new or previous diagnosis of epilepsy were excluded from the study.

Results: Evaluation was made of 88 patients, comprising 35 (39.8%) girls and 53 (60.2%) boys with a mean age of 10.6 ± 4.3 years. In the analysis of the patients who did not sleep at all during the EEG recording, the drugs administered to the patients for sedation were observed to be hydroxyzine in 4 (14.8%) patients, chloral hydrate in 1 (2.8%) patient, and melatonin in 5 (20%) patients. Sleep duration was seen to be longer and the rates of motion artifacts and awakening during filming were lower in the patients treated with chloral hydrate.

Conclusions: The results of this study showed that chloral hydrate was the most effective drug for inducing sleep. There is a need for further similar prospective studies to be performed on patients diagnosed with epilepsy and those aged <4 years. Possible complications should be considered before using each agent for sleep induction.