The potential of curcumin in mitigating acetaminophen-induced liver damage.

Abstract

Acetaminophen (APAP) is a widely used over-the-counter medication for pain and fever, but its overuse can lead to liver toxicity, hepatocyte apoptosis, and necrosis. Despite therapeutic advances in drug-induced hepatotoxicity, APAP-induced liver damage still poses a medical challenge. Recently, natural products have emerged as potential options for mitigating the effects of APAP hepatotoxicity. Curcumin, a natural compound with antioxidant and anti-inflammatory properties, has shown promising results in drug-induced hepatotoxicity. However, further investigations are needed to assess the clinical benefits of curcumin. In this review, we discuss the mechanisms of APAP-induced liver damage and the role of curcumin in preventing liver necrosis, oxidative stress, inflammation, and apoptosis caused by APAP overdose. Through its ability to scavenge free radicals, prevent lipid peroxidation, restore glutathione (GSH) levels, and inhibit apoptosis, curcumin has been found to significantly reduce oxidative stress and protect liver tissue from APAP toxicity in various studies. This paper also reviews the potential of novel nanoformulations to enhance the bioavailability of curcumin for improved therapeutic outcomes. Overall, the evidence suggests that curcumin could be a promising intervention to mitigate the harmful effects of APAP overdose and improve liver health. However, further research is required to assess the optimal dosing and timing of curcumin administration in APAP toxicity.