Physicochemical and Sensory Evaluation of Sustainable Plant-Based Homopolymers as an Alternative to Traditional Emollients in Topical Emulsions.

IF 5.5 3区 医学 Q1 PHARMACOLOGY & PHARMACY Pharmaceutics Pub Date : 2025-02-17 DOI:10.3390/pharmaceutics17020265
Talita Ganem Meneguello, Nathalia Kopke Palma, Yasmin Rosa Santos, Ariel Figueira Carvalho, Ariane Dalan da Silva Ladeira, Fabiana Perrechil Bonsanto, Newton Andreo-Filho, Patricia Santos Lopes, Heather Ann Elizabeth Benson, Vania Rodrigues Leite-Silva
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Abstract

Objectives: This study evaluated the potential of sustainably sourced, plant-based homopolymers derived from citronellol as an alternative to the traditional emollients used in pharmaceutical, cosmetic, and personal care products. With increasing emphasis on environmentally friendly ingredients and manufacturing processes, this study assessed the efficacy of these homopolymers in semi-solid and emulsion-based formulations. Methods: The analyses focused on physicochemical, sensory, biophysical, and neurosensory characteristics. Results: The results demonstrated that emulsions containing sustainable homopolymers maintained viscoelastic stability, preserving rheological properties over time under varying conditions. These formulations showed comparable structural and functional stability to those with traditional emollients while offering skin hydration, moisture retention, and elasticity, with reduced transepidermal water loss. Sensory evaluations highlighted positive user acceptance, with participants favoring the skin feel and in-use qualities of these emulsions over synthetic alternatives. Neurosensory analyses confirmed the strong visual appeal of the product packaging, capturing user attention effectively. Conclusions: These findings underline the capability of plant-based homopolymers to replace traditional emollients while providing significant consumer appeal and sustainability benefits. This study establishes their potential as viable components in the development of more eco-friendly topical formulations for the pharmaceutical, cosmetic, and personal care industries.

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可持续植物基均聚物作为局部乳液中传统润肤剂的替代品的物理化学和感官评价。
目的:本研究评估了从香茅醇中提取的可持续来源的植物基均聚物作为传统润肤剂的替代品的潜力,这些润肤剂用于制药、化妆品和个人护理产品。随着对环保成分和制造工艺的日益重视,本研究评估了这些均聚物在半固体和乳基配方中的功效。方法:从理化、感觉、生物物理、神经感觉等方面进行分析。结果:结果表明,含有可持续均聚物的乳液保持粘弹性稳定性,在不同条件下随时间保持流变性能。这些配方显示出与传统润肤剂相当的结构和功能稳定性,同时提供皮肤补水、保湿和弹性,减少经皮水分流失。感官评估强调了积极的用户接受度,参与者更喜欢这些乳液的皮肤感觉和使用质量,而不是合成替代品。神经感官分析证实了产品包装的强烈视觉吸引力,有效地抓住了用户的注意力。结论:这些发现强调了植物基均聚物取代传统润肤剂的能力,同时提供了显著的消费者吸引力和可持续性效益。本研究确定了它们作为可行成分的潜力,可用于制药、化妆品和个人护理行业开发更环保的局部配方。
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来源期刊
Pharmaceutics
Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
7.90
自引率
11.10%
发文量
2379
审稿时长
16.41 days
期刊介绍: Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications,  and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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