The Sex-Dependent Ameliorative Effect of Intermittent Fasting on Urinary System Functions in Genetic Absence Epileptic Rats.

IF 3.5 3区生物学 Q1 BIOLOGY Biology-Basel Pub Date : 2025-02-04 DOI:10.3390/biology14020158

Damla Gökçeoğlu-Kayalı, Mehmet Ali Berkyürek, Zarife Nigar Özdemir-Kumral, Özlem Tuğçe Çilingir-Kaya

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Abstract

Epilepsy, a brain condition causing recurrent seizures, can disrupt various body functions, including urination. This study explored how alternate-day fasting (ADF), a type of intermittent fasting, a diet involving one day of eating and fasting, subsequently affects urinary system health in epileptic rats. Using a genetic rat model of epilepsy, we examined bladder and kidney function through tissue analysis, biochemical tests, and physiological assessments, focusing on differences between males and females. The results showed that epilepsy causes significant urinary system damage linked to inflammation and oxidative stress. However, ADF reduces this damage by lowering inflammation and restoring antioxidant balance. Male rats exhibited more oxidative damage, while female rats responded better to ADF, likely due to hormonal differences. These findings suggest ADF as a potential, cost-effective dietary approach to protect against urinary complications in epilepsy and similar conditions. Understanding these effects may lead to improved treatments for both genders and a better quality of life for people with chronic diseases.

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间歇性禁食对遗传性缺失癫痫大鼠泌尿系统功能的性别依赖性改善作用。

癫痫是一种引起反复发作的脑部疾病，它会扰乱包括排尿在内的各种身体功能。这项研究探讨了隔日禁食（ADF），一种间歇性禁食，一种包括一天进食和禁食的饮食，如何随后影响癫痫大鼠的泌尿系统健康。利用癫痫遗传大鼠模型，我们通过组织分析、生化测试和生理评估来检查膀胱和肾脏功能，重点研究雄性和雌性之间的差异。结果表明，癫痫会导致与炎症和氧化应激有关的严重泌尿系统损伤。然而，ADF通过降低炎症和恢复抗氧化平衡来减少这种损害。雄性大鼠表现出更多的氧化损伤，而雌性大鼠对ADF的反应更好，可能是由于激素的差异。这些发现表明，ADF是一种潜在的、具有成本效益的饮食方法，可预防癫痫和类似疾病的泌尿系统并发症。了解这些影响可能会改善男女的治疗方法，并提高慢性病患者的生活质量。

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来源期刊

Biology-Basel Biological Science-Biological Science

CiteScore

5.70

自引率

4.80%

发文量

1618

审稿时长

11 weeks

期刊介绍： Biology (ISSN 2079-7737) is an international, peer-reviewed, quick-refereeing open access journal of Biological Science published by MDPI online. It publishes reviews, research papers and communications in all areas of biology and at the interface of related disciplines. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files regarding the full details of the experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.