A study on the willingness and influencing factors of non-EPI vaccines recommendations among Chinese vaccination staff under major infectious disease outbreaks.

IF 3.5 4区 医学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Human Vaccines & Immunotherapeutics Pub Date : 2025-12-01 Epub Date: 2025-02-26 DOI:10.1080/21645515.2025.2469987
Xie Qixin, Yan Liu, Xinren Che, Jian Du, Yuyang Xu, Jiayin Han, Zhaojun Lu, Yingying Yang, Wenwen Gu
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Abstract

WHO had warned of the impending "X disease," emphasizing the need to quickly establish an immune barrier. The willingness of vaccination staff to recommend vaccines was crucial in such scenarios. This study aimed to investigate willingness and influencing factors of Non-EPI Vaccines recommendations among Chinese vaccination staff in Hangzhou, China. We selected vaccination staff in 191 vaccination clinics from Hangzhou for a questionnaire-based survey using a cross-sectional survey. Descriptive statistics were made on the characteristics of participants. Univariate and multivariable analyses were used to determine the influencing factors of Non-EPI Vaccines recommendations. The overall recommendation rate was 76.2%. Compared to Supplementary and Individual Non-EPI Vaccines, vaccination staff were more willing to recommend Alternative (x2 = 215.655, P < 0.05) and Combined Non-EPI Vaccines (x2 = 214.998, P < 0.05). Multivariate logistic regression analysis showed that vaccination staff who did not participate in COVID-19 vaccination work (OR = 2.942, 95%CI:1.121 ~ 9.302), believe they had an obligation to recommend Non-EPI Vaccines (OR disagree = 7.957, 95%CI:1.238 ~ 87.69; OR neutrality = 4.187, 95%CI:1.66 ~ 10.563), and think that the effects of non-routine immunization vaccines were very good (OR disagree = 3.133, 95%CI:1.677 ~ 14.495; OR neutrality = 2.512, 95%CI:1.164 ~ 5.418) were more willing to recommend Non-EPI Vaccines. On the contrary, vaccination staff who believe that recommending Non-EPI vaccines increased their workload (OR disagree = 0.307, 95%CI:0.11 ~ 0.856; OR neutrality = 0.642, 95%CI:0.258 ~ 0.986) would decrease willingness to recommend them. The most of vaccination staff were willing to recommend non-EPI vaccines under major infectious disease outbreaks. To further control the pandemic of major infectious diseases, the health management departments should enhance the knowledge of vaccines among vaccination staff and alleviate their workload.

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重大传染病疫情下预防接种人员推荐非计划免疫疫苗意愿及影响因素研究
世卫组织对即将到来的“X疾病”发出警告,强调需要迅速建立免疫屏障。在这种情况下,疫苗接种工作人员是否愿意推荐疫苗至关重要。本研究旨在了解杭州市接种人员推荐非计划免疫疫苗的意愿及其影响因素。采用横断面调查法,对杭州市191家疫苗接种诊所的接种人员进行问卷调查。对参与者的特征进行描述性统计。采用单变量和多变量分析确定非扩大免疫疫苗推荐的影响因素。总体推荐率为76.2%。接种人员推荐替代疫苗(x2 = 215.655, P < 0.05)和联合疫苗(x2 = 214.998, P < 0.05)的意愿高于补充疫苗和单项非扩大免疫疫苗。多因素logistic回归分析显示,未参与新冠肺炎疫苗接种工作的接种人员(OR = 2.942, 95%CI:1.121 ~ 9.302)认为有义务推荐非扩大免疫疫苗(OR = 7.957, 95%CI:1.238 ~ 87.69);OR中性= 4.187,95%CI:1.66 ~ 10.563),认为非常规免疫疫苗效果很好(OR不一致= 3.133,95%CI:1.677 ~ 14.495;OR中性= 2.512,95%CI:1.164 ~ 5.418)更愿意推荐非扩大免疫疫苗。相反,接种人员认为推荐非扩大免疫疫苗增加了他们的工作量(OR不同意= 0.307,95%CI:0.11 ~ 0.856;OR中立性= 0.642,95%CI:0.258 ~ 0.986)会降低推荐意愿。大多数疫苗接种工作人员愿意在重大传染病暴发时推荐非扩大免疫方案疫苗。为进一步控制重大传染病的流行,卫生管理部门应提高预防接种人员的疫苗知识,减轻预防接种人员的工作量。
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来源期刊
Human Vaccines & Immunotherapeutics
Human Vaccines & Immunotherapeutics BIOTECHNOLOGY & APPLIED MICROBIOLOGY-IMMUNOLOGY
CiteScore
7.90
自引率
8.30%
发文量
489
审稿时长
3-6 weeks
期刊介绍: (formerly Human Vaccines; issn 1554-8619) Vaccine research and development is extending its reach beyond the prevention of bacterial or viral diseases. There are experimental vaccines for immunotherapeutic purposes and for applications outside of infectious diseases, in diverse fields such as cancer, autoimmunity, allergy, Alzheimer’s and addiction. Many of these vaccines and immunotherapeutics should become available in the next two decades, with consequent benefit for human health. Continued advancement in this field will benefit from a forum that can (A) help to promote interest by keeping investigators updated, and (B) enable an exchange of ideas regarding the latest progress in the many topics pertaining to vaccines and immunotherapeutics. Human Vaccines & Immunotherapeutics provides such a forum. It is published monthly in a format that is accessible to a wide international audience in the academic, industrial and public sectors.
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