Mexico's Laboratory-Confirmed Human Case of Infection with the Influenza A(H5N2) Virus.

IF 3.5 3区 医学 Q2 VIROLOGY Viruses-Basel Pub Date : 2025-01-31 DOI:10.3390/v17020205
Joel Armando Vázquez-Pérez, Claudia Wong-Arámbula, Mario Solís-Hernández, Eduardo Becerril-Vargas, Gisela Barrera-Badillo, Víctor Hugo Ahumada-Topete, Santiago Avila-Rios, Rogelio Pérez-Padilla, Fidencio Mejía-Nepomuceno, Enrique Mendoza-Ramírez, Marisol Karina Rocha-Martinez, Carlos Javier Alcazar-Ramiro, Alfredo Cruz, Joaquin Zúñiga, Karolina Bozena Piekarska, Dayanira Sarith Arellano-Suarez, María Natividad Cruz-Ortiz, Tatiana Ernestina Núñez-García, Eréndira Molina-Gómez, Laura Adriana Flores-Cisneros, Rodrigo Aparicio-Antonio, Abril Rodríguez-Maldonado, Magaly Landa-Flores, Armando García-López, Jorge Membrillo-Hernández, Gabriel García-Rodríguez, Herlinda García-Lozano, Irma López-Martínez, Ruth Purisima González-Sánchez, Carmen Margarita Hernández-Cárdenas
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Abstract

In April 2024, the Instituto Nacional de Enfermedades Respiratorias of Mexico City identified a case of unsubtypeable Influenza A in a 58-year-old immunocompromised patient with renal failure due to diabetic nephropathy and bacterial peritonitis. Through sequencing the M, NS, NA, NP, and HA complete segments, we identified an H5N2 influenza virus with identity of 99% with avian influenza A(H5N2) from Texcoco, Mexico, in 2024. This case is the first reported with direct evidence of human infection caused by the H5N2 influenza virus; the relationship of the virus with the severity of his condition remains unknown.

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墨西哥实验室确认的人类感染甲型流感(H5N2)病毒病例。
2024年4月,墨西哥城国立呼吸系统研究所在一名58岁的免疫功能低下患者中发现了一例无法分型的甲型流感,该患者因糖尿病肾病和细菌性腹膜炎导致肾功能衰竭。通过M、NS、NA、NP和HA全片段测序,鉴定出一株h5n1型禽流感病毒,其与2024年墨西哥Texcoco地区甲型禽流感(H5N2)的同源性为99%。该病例是报告的第一例有H5N2流感病毒引起的人感染直接证据的病例;这种病毒与他病情的严重程度之间的关系尚不清楚。
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来源期刊
Viruses-Basel
Viruses-Basel VIROLOGY-
CiteScore
7.30
自引率
12.80%
发文量
2445
审稿时长
1 months
期刊介绍: Viruses (ISSN 1999-4915) is an open access journal which provides an advanced forum for studies of viruses. It publishes reviews, regular research papers, communications, conference reports and short notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. We also encourage the publication of timely reviews and commentaries on topics of interest to the virology community and feature highlights from the virology literature in the ''News and Views'' section. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.
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