Daniela Maria Tanase, Emilia Valasciuc, Evelina Maria Gosav, Mariana Floria, Oana Nicoleta Buliga-Finis, Anca Ouatu, Andrei Ionut Cucu, Tina Botoc, Claudia Florida Costea
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引用次数: 0
Abstract
Diabetic retinopathy (DR), a leading cause of vision impairment worldwide, is characterized by progressive damage to the retina due to prolonged hyperglycemia. Despite advances in treatment, current interventions largely target late-stage vascular complications, leaving underlying neurodegenerative processes insufficiently addressed. This article explores the crucial role in neuronal survival, axonal growth, and synaptic plasticity and the neuroprotective potential of Brain-Derived Neurotrophic Factor (BDNF) as a therapeutic strategy for enhancing retinal resilience in DR. Furthermore, it discusses innovative delivery methods for BDNF, such as gene therapy and nanocarriers, which may overcome the challenges of achieving sustained and targeted therapeutic levels in the retina, focusing on early intervention to preserve retinal function and prevent vision loss.
糖尿病视网膜病变（DR）是全球视力受损的主要原因，其特点是视网膜因长期高血糖而逐渐受损。尽管在治疗方面取得了进展，但目前的干预措施主要针对晚期血管并发症，而对潜在的神经退行性病变过程却未给予足够重视。本文探讨了脑源性神经营养因子（BDNF）在神经元存活、轴突生长和突触可塑性中的关键作用，以及其作为增强 DR 视网膜复原力的治疗策略的神经保护潜力。此外，报告还讨论了 BDNF 的创新给药方法，如基因疗法和纳米载体，这些方法可以克服在视网膜中实现持续和有针对性的治疗水平所面临的挑战，重点关注早期干预，以保护视网膜功能和防止视力丧失。
Life-BaselBiochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology
CiteScore
4.30
自引率
6.20%
发文量
1798
审稿时长
11 weeks
期刊介绍：
Life (ISSN 2075-1729) is an international, peer-reviewed open access journal of scientific studies related to fundamental themes in Life Sciences, especially those concerned with the origins of life and evolution of biosystems. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers.
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