{"title":"An overview of recent advances in enantioselective multicomponent reactions","authors":"Atieh Rezvanian , Elham Mardi , Pezhman Shiri","doi":"10.1016/j.molstruc.2025.141768","DOIUrl":null,"url":null,"abstract":"<div><div>Sequential transformations of three or more substrates in multicomponent reactions are known to yield architecturally intricate products. A vast majority of substrate components are transformed into the intended products with minimal generation of byproducts. The efficiency and variety of these reactions have led to their prominence in synthetic organic chemistry. Recently, the importance of enantioselective multicomponent processes has grown, especially in the domain of pharmaceutical and biological molecule synthesis, due to the unique biological properties displayed by enantiomers and diastereomers. The objective of the present review article is to provide an overview of the progress made in the enantioselective synthesis of compounds using multicomponent reactions, focusing on recent publications.</div></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":"1334 ","pages":"Article 141768"},"PeriodicalIF":4.7000,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Structure","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022286025004545","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Sequential transformations of three or more substrates in multicomponent reactions are known to yield architecturally intricate products. A vast majority of substrate components are transformed into the intended products with minimal generation of byproducts. The efficiency and variety of these reactions have led to their prominence in synthetic organic chemistry. Recently, the importance of enantioselective multicomponent processes has grown, especially in the domain of pharmaceutical and biological molecule synthesis, due to the unique biological properties displayed by enantiomers and diastereomers. The objective of the present review article is to provide an overview of the progress made in the enantioselective synthesis of compounds using multicomponent reactions, focusing on recent publications.
期刊介绍：
The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including:
• Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.)
• Chemical intermediates
• Molecules in excited states
• Biological molecules
• Polymers.
The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example:
• Infrared spectroscopy (mid, far, near)
• Raman spectroscopy and non-linear Raman methods (CARS, etc.)
• Electronic absorption spectroscopy
• Optical rotatory dispersion and circular dichroism
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• Electron spectroscopies (PES, XPS), EXAFS, etc.
• Microwave spectroscopy
• Electron diffraction
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• Computational Studies (supplementing experimental methods)
We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.
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