Beta-band power modulation in the human amygdala during a delayed reach task

Abstract

Introduction

The amygdala is mostly known for its roles in emotional processing and social behavior. In recent years, it has been implicated in voluntary motor control due to its structural and functional connectivity with the motor cortex. By investigating whether the amygdala modulates during movement preparation, we can further examine its contributions to motor processing.

Objective

We utilized a delayed reach task to measure beta-band (13–30 Hz) modulation in the amygdala during movement preparation. We hypothesized that we would see decreases in beta-band power during the Delay and Response phases of this task.

Methods

Eleven subjects diagnosed with drug-resistant epilepsy (DRE), who were implanted with stereoelectroencephalographic (SEEG) electrodes, were recruited to this study. The beta-band power was recorded through a delayed reach task. We calculated the beta-band Power Spectral Density (PSD) using multi-taper spectral analysis and compared the trial-averaged PSD using a cluster-based permutation test to determine the significance of beta-band power differences between task phases.

Results

100 % of participants and 44.8 % of gray matter contacts in the amygdala (n = 58) exhibited significantly decreased beta-band power during the Delay phase. During the Response phase, 90.9 % of participants and 58.6 % of gray matter contacts (n = 58) showed significantly decreased beta-band power. We also found a difference in the proportion of amygdala contacts showing beta-band modulation between those implanted in gray vs. white matter (p = 0.0035) but found no difference between contralateral vs. ipsilateral contacts (p = 0.17) and male vs. female participants (p = 0.34).

Conclusion

This study is the first to demonstrate beta-band power decreases in the amygdala during the Delay and Response phases of a delayed reach task. These findings demonstrate that the amygdala undergoes neural modulation prior to movement initiation and during movement execution.