{"title":"The role of lactylation in virology","authors":"Sirui Wang , Leiliang Zhang","doi":"10.1016/j.virol.2025.110466","DOIUrl":null,"url":null,"abstract":"<div><div>Lactylation, a novel post-translational protein modification, is increasingly recognized for its widespread occurrence on lysine residues in both histone and non-histone proteins. Recent research has primarily focused on its implications in specific human diseases, particularly cancer progression, metabolic disorders, neurodegenerative diseases, and immune responses. However, it is crucial to acknowledge the significant roles played by viruses as pathogens in both clinical and veterinary medicine, as well as in zoological and phytopathological studies. This review highlights the latest advancements in understanding the mechanisms underlying lactylation and its regulation, emphasizing the role of lactylation in certain viruses. We discuss its involvement in essential biological functions, the pathogenic mechanisms of various viruses, host-virus interactions, and practical applications, including the potential for lactylation to serve as a therapeutic target in disease pathogenesis. Exploring the interactions between viruses and lactylation presents a promising research direction that may help refine the emerging concept of lactylation.</div></div>","PeriodicalId":23666,"journal":{"name":"Virology","volume":"605 ","pages":"Article 110466"},"PeriodicalIF":2.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Virology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0042682225000789","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/25 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"VIROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Lactylation, a novel post-translational protein modification, is increasingly recognized for its widespread occurrence on lysine residues in both histone and non-histone proteins. Recent research has primarily focused on its implications in specific human diseases, particularly cancer progression, metabolic disorders, neurodegenerative diseases, and immune responses. However, it is crucial to acknowledge the significant roles played by viruses as pathogens in both clinical and veterinary medicine, as well as in zoological and phytopathological studies. This review highlights the latest advancements in understanding the mechanisms underlying lactylation and its regulation, emphasizing the role of lactylation in certain viruses. We discuss its involvement in essential biological functions, the pathogenic mechanisms of various viruses, host-virus interactions, and practical applications, including the potential for lactylation to serve as a therapeutic target in disease pathogenesis. Exploring the interactions between viruses and lactylation presents a promising research direction that may help refine the emerging concept of lactylation.
期刊介绍：
Launched in 1955, Virology is a broad and inclusive journal that welcomes submissions on all aspects of virology including plant, animal, microbial and human viruses. The journal publishes basic research as well as pre-clinical and clinical studies of vaccines, anti-viral drugs and their development, anti-viral therapies, and computational studies of virus infections. Any submission that is of broad interest to the community of virologists/vaccinologists and reporting scientifically accurate and valuable research will be considered for publication, including negative findings and multidisciplinary work.Virology is open to reviews, research manuscripts, short communication, registered reports as well as follow-up manuscripts.
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