The role of lactate and lactylation in ischemic cardiomyopathy: Mechanisms and gene expression

IF 3.7 4区医学 Q2 PATHOLOGY Experimental and molecular pathology Pub Date : 2025-03-01 Epub Date: 2025-02-27 DOI:10.1016/j.yexmp.2025.104957

Mei Zhang , Xue Kong , Chenlu Wu , Jiuhong Li , Hui Yang , Lingzhi Huang

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Abstract

Ischemic cardiomyopathy (ICM) is a significant global public health issue, with its pathophysiology encompassing atherosclerotic plaque formation, thrombosis, hypoperfusion, ischemic cell death, and left ventricular remodeling. Lactate is not only regarded as an energy metabolite but also acts as a signaling molecule that influences various physiological processes, regulating metabolism and muscle contraction. Lactylation, an emerging epigenetic modification, affects protein functionality and gene expression through the P300 enzyme. In ICM, lactate accumulation leads to pH imbalance and myocardial cell dysfunction, impacting cellular signaling. This paper will analyze the role of lactylation in ICM, focusing on coronary artery disease (ASCVD) and myocardial infarction (MI). It will also explore the differential expression and immunological characteristics of lactylation-related genes in normal and ICM tissues, providing potential targets for future research.

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乳酸和乳酸化在缺血性心肌病中的作用：机制和基因表达

缺血性心肌病（ICM）是一个重要的全球公共卫生问题，其病理生理学包括动脉粥样硬化斑块形成、血栓形成、灌注不足、缺血性细胞死亡和左心室重构。乳酸不仅被认为是一种能量代谢物，而且作为一种影响各种生理过程的信号分子，调节代谢和肌肉收缩。乳酸化是一种新兴的表观遗传修饰，通过P300酶影响蛋白质功能和基因表达。在ICM中，乳酸积累导致pH失衡和心肌细胞功能障碍，影响细胞信号传导。本文将分析乳酸化在ICM中的作用，重点是冠状动脉疾病（ASCVD）和心肌梗死（MI）。探索正常组织和ICM组织中乳酸化相关基因的差异表达和免疫学特征，为今后的研究提供潜在的靶点。

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来源期刊

Experimental and molecular pathology 医学-病理学

CiteScore

8.90

自引率

0.00%

发文量

审稿时长

11.5 weeks

期刊介绍： Under new editorial leadership, Experimental and Molecular Pathology presents original articles on disease processes in relation to structural and biochemical alterations in mammalian tissues and fluids and on the application of newer techniques of molecular biology to problems of pathology in humans and other animals. The journal also publishes selected interpretive synthesis reviews by bench level investigators working at the "cutting edge" of contemporary research in pathology. In addition, special thematic issues present original research reports that unravel some of Nature''s most jealously guarded secrets on the pathologic basis of disease. Research Areas include: Stem cells; Neoangiogenesis; Molecular diagnostics; Polymerase chain reaction; In situ hybridization; DNA sequencing; Cell receptors; Carcinogenesis; Pathobiology of neoplasia; Complex infectious diseases; Transplantation; Cytokines; Flow cytomeric analysis; Inflammation; Cellular injury; Immunology and hypersensitivity; Athersclerosis.