Tanfloc-Modified Titanium Surfaces: Optimizing Blood Coagulant Activity and Stem Cell Compatibility.

IF 5.5 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Biomaterials Science & Engineering Pub Date : 2025-03-10 Epub Date: 2025-02-27 DOI:10.1021/acsbiomaterials.4c02106

Ramesh Singh, Liszt Y C Madruga, Aniruddha Savargaonkar, Alessandro F Martins, Matt J Kipper, Ketul C Popat

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Abstract

This study explores the synergistic effects of combining titania nanotubes (TiNTs) with the biopolymer Tanfloc (TAN) to enhance the surface properties of TiNTs for biomedical applications. We investigated the interactions of blood components and human adipose-derived stem cells (ADSCs) with TiNT surfaces covalently functionalized with Tanfloc (TAN), an aminolyzed polyphenolic tannin derivative. The functionalized surfaces (TiNT-TAN) have great potential to control protein adsorption and platelet adhesion and activation. Fluorescence and scanning electron microscopy (SEM) were used to analyze platelet adherence and activation. The amphoteric nature and multiple functional groups on TAN can control blood protein adsorption, platelet adhesion, and activation. Further, the modified surface supports adipose-derived stem cell (ADSC) viability, attachment, and growth without any cytotoxic effect. The TAN conjugation significantly (****p < 0.0001) increased the proliferation rate of ADSCs compared to the TiNT surfaces.

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tanflo改性钛表面：优化血液凝固活性和干细胞相容性。

本研究探讨了钛纳米管（TiNTs）与生物聚合物Tanfloc （TAN）结合的协同效应，以提高TiNTs的表面性能，用于生物医学应用。我们研究了血液成分和人类脂肪源性干细胞（ADSCs）的相互作用，这些细胞的TiNT表面被Tanfloc （TAN）共价功能化，Tanfloc是一种氨基水解的多酚单宁衍生物。功能化表面（TiNT-TAN）在控制蛋白质吸附和血小板粘附和活化方面具有很大的潜力。荧光和扫描电镜（SEM）分析血小板粘附和活化情况。TAN的两性性质和多个官能团可控制血液蛋白吸附、血小板粘附和活化。此外，修饰的表面支持脂肪源性干细胞（ADSC）的活力、附着和生长，而没有任何细胞毒性作用。与TiNT表面相比，TAN结合显著提高了ADSCs的增殖率（****p < 0.0001）。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

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