Triangesinenolides A-C: Trimeric Phthalides with Anti-Renal Fibrosis Potential from Angelica sinensis.

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC Organic Letters Pub Date : 2025-03-07 Epub Date: 2025-02-26 DOI:10.1021/acs.orglett.5c00317

Hang Lv, Yu Mu, Bixuan Cao, Ping Yi, Nuerbiye Aobulikasimu, Zhongyuan Liu, Xueshi Huang, Li Han

引用次数: 0

Abstract

Trimeric phthalides in nature are rarely reported. This research successfully isolated three novel trimeric phthalides, triangesinenolides A-C (1-3), from Angelica sinensis. These compounds, derived from Z-ligustilide via diverse linkage patterns, display intricate polycyclic skeletons. Their structures were confirmed by spectroscopic and crystallographic analyses. Unlike previously identified trimeric phthalides, triangesinenolide C (3) is the first trimeric phthalide synthesized via [2 + 2]/[4 + 2] cycloaddition. In vitro assays evaluated the anti-renal fibrosis activity of trimeric phthalides for the first time.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.