Beta Burst Characteristics and Coupling within the Sensorimotor Cortical-Subthalamic Nucleus Circuit Dynamically Relate to Bradykinesia in Parkinson's Disease

IF 7.6 1区医学 Q1 CLINICAL NEUROLOGY Movement Disorders Pub Date : 2025-02-27 DOI:10.1002/mds.30163

Pan Yao PhD, Abhinav Sharma PhD, Bahman Abdi-Sargezeh PhD, Tao Liu MSc, Huiling Tan PhD, Amelia Hahn BA, Philip Starr MD, PhD, Simon Little MD, PhD, Ashwini Oswal MD, PhD

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Abstract

Background

Bursts of exaggerated subthalamic nucleus (STN) beta activity are believed to contribute to clinical impairments in Parkinson's disease (PD). No previous studies have explored burst characteristics and coupling across the sensorimotor cortical-STN circuit and determined their relationship to dynamic measurements of bradykinesia.

Objective

We sought to (1) establish the characteristics of sensorimotor cortical and STN bursts during naturalistic behaviors, (2) determine the predictability of STN bursts from motor cortical recordings, and (3) relate burst features to continuous measurements of bradykinesia using wearable sensors.

Methods

We analyzed 1046 h of wirelessly streamed bilateral sensorimotor cortical and STN recordings from 5 PD patients with concurrent measurements of bradykinesia.

Results

STN bursts were longer than cortical bursts and had shorter inter-burst intervals. Long bursts (>200 ms) in both structures displayed temporal overlap (>30%), with cortical bursts tending to lead STN burst onset by 8 ms. Worsening bradykinesia was linked to increased cortical burst rates and durations, whereas STN burst properties had the opposite effect.

Conclusion

Cortical beta bursts tend to precede STN beta bursts with short delays and their occurrence relates to worsening bradykinesia in naturalistic settings. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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感觉运动皮层-丘脑底核回路内的β爆发特征和耦合与帕金森病运动迟缓动态相关。

背景：过度的丘脑下核(STN) β活动爆发被认为是帕金森病（PD）临床损伤的原因之一。以前没有研究探索过感觉运动皮层- stn回路的爆发特征和耦合，并确定它们与运动迟缓的动态测量的关系。目的：我们试图(1)建立自然行为时感觉运动皮层和STN爆发的特征，(2)从运动皮层记录中确定STN爆发的可预测性，以及(3)使用可穿戴传感器将爆发特征与运动迟缓的连续测量相关联。方法：我们分析了5名PD患者1046小时的无线流双侧感觉运动皮层和STN记录，同时测量运动迟缓。结果：STN脉冲比皮质脉冲长，间隔时间短。两个结构的长脉冲（>200 ms）表现出时间重叠（>30%），皮层脉冲倾向于比STN脉冲早8 ms。运动迟缓的恶化与皮层爆发率和持续时间的增加有关，而STN爆发特性具有相反的作用。结论：皮层β -爆发倾向于先于STN β -爆发，并有短暂的延迟，它们的发生与自然环境下运动迟缓的恶化有关。©2025作者。Wiley期刊有限责任公司代表国际帕金森和运动障碍学会出版的《运动障碍》。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders 医学-临床神经学

CiteScore

13.30

自引率

8.10%

发文量

371

审稿时长

12 months

期刊介绍： Movement Disorders publishes a variety of content types including Reviews, Viewpoints, Full Length Articles, Historical Reports, Brief Reports, and Letters. The journal considers original manuscripts on topics related to the diagnosis, therapeutics, pharmacology, biochemistry, physiology, etiology, genetics, and epidemiology of movement disorders. Appropriate topics include Parkinsonism, Chorea, Tremors, Dystonia, Myoclonus, Tics, Tardive Dyskinesia, Spasticity, and Ataxia.