Clinical and laboratory characteristics of neurosyphilis: analysis of symptoms and risk factors.

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL European Journal of Medical Research Pub Date : 2025-02-26 DOI:10.1186/s40001-025-02349-1

Ekaterina Orlova, Igor Gadaev, Lyudmila Smirnova, Natalia Kolenko, Elena Zykova

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Abstract

Background: The present study was conducted from 2021 to 2023 to analyze the clinical and laboratory characteristics of neurosyphilis and determine the risk factors associated with this condition.

Methods: A total of 400 patients were enrolled, including 100 individuals diagnosed with neurosyphilis, 100 without neurosyphilis, 100 with latent syphilis, and 100 healthy control subjects. Comparative analysis methods, serum VDRL titration, and correlation analysis were employed during the study.

Results: The analysis revealed significant differences in symptoms of central nervous system (CNS) involvement and serum VDRL titers among the patient groups. For instance, symptoms indicative of CNS impairment were more frequently observed in patients with neurosyphilis, and serum VDRL titers were statistically significantly higher in this same group.

Conclusions: The obtained results can be utilized in clinical practice to enhance the accuracy of neurosyphilis diagnosis and management, thereby contributing to the improvement of early detection of this condition and prevention of its complications. The study allows for the inference of the importance of early detection of (CNS) dysfunction symptoms in patients (neurosyphilis) with syphilis and identifies key factors influencing the development of this disease. The findings hold significance for the diagnosis and treatment of neurosyphilis.

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神经梅毒的临床和实验室特征：症状和危险因素分析。

背景：本研究于2021年至2023年进行，分析神经梅毒的临床和实验室特征，并确定与该疾病相关的危险因素。方法：共纳入400例患者，其中诊断为神经梅毒者100例，未诊断为神经梅毒者100例，潜伏性梅毒者100例，健康对照100例。研究中采用对比分析法、血清VDRL滴定法和相关性分析法。结果：分析显示各组患者中枢神经系统（CNS）受累症状和血清VDRL滴度有显著差异。例如，在神经梅毒患者中更常观察到中枢神经系统损伤的症状，并且在同一组中血清VDRL滴度具有统计学显著性升高。结论：所得结果可用于临床实践，提高神经梅毒的诊断和治疗的准确性，有助于提高神经梅毒的早期发现和并发症的预防。该研究推断了梅毒患者（神经梅毒）早期检测（中枢神经系统）功能障碍症状的重要性，并确定了影响该疾病发展的关键因素。本研究结果对神经梅毒的诊断和治疗具有重要意义。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.