Association of PTX3 Genetic Variants With Development of Diabetic Neuropathy.

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL In vivo Pub Date : 2025-03-01 DOI:10.21873/invivo.13874

Yung-Nan Hsu, Ying-Chi Fan, Shih-Chi Su, Lun-Ching Chang, Shun-Fa Yang

{"title":"Association of PTX3 Genetic Variants With Development of Diabetic Neuropathy.","authors":"Yung-Nan Hsu, Ying-Chi Fan, Shih-Chi Su, Lun-Ching Chang, Shun-Fa Yang","doi":"10.21873/invivo.13874","DOIUrl":null,"url":null,"abstract":"Background/aim: Pentraxin 3 (PTX3), initially discovered as a key player in the defense against infectious pathogens, is crucial for inflammation and tissue regeneration. This study aimed to explore the impact of PTX3 gene variants on the development and progression of diabetic neuropathy (DN).Materials and methods: The potential impact of PTX3 gene variants on the susceptibility to DN was examined by genotyping four single-nucleotide polymorphisms (SNPs) of the PTX3 gene (rs1840680, rs2305619, rs3816527, and rs2120243) in a study involving 730 DN cases and 861 diabetic controls with normal neurologic function.Results: We demonstrated that diabetic subjects homozygous for the minor allele at rs1840680 [AA; adjusted odds ratio (AOR)=1.486; 95% confidence interval (CI)=1.050-2.103; p=0.02] or rs2120243 (AA; AOR=1.483; 95%CI=1.051-2.091; p=0.025) were more likely to develop neurologic complications compared to those homozygous for the corresponding major allele. Further stratification revealed that this correlation with DN risk was observed specifically in males but not in females. In addition, another SNP of the PTX3 gene, rs2305619, was found to be associated with the risk for DN in males (AA vs. GG, AOR=1.686; 95%CI=1.086-2.617, p=0.020), indicating a sex-specific impact of PTX3 gene polymorphisms on damage to the nerves in diabetic patients. Furthermore, DN patients homozygous for the minor allele of rs1840680 (AA), particularly males, had higher levels of LDL-cholesterol than those homozygous for the reference allele (GG) (p=0.034).Conclusion: PTX3 gene polymorphisms are associated with dyslipidemia and nerve damage in diabetic patients in a sex-specific manner.","PeriodicalId":13364,"journal":{"name":"In vivo","volume":"39 2","pages":"702-712"},"PeriodicalIF":1.8000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"In vivo","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.21873/invivo.13874","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

Abstract

Background/aim: Pentraxin 3 (PTX3), initially discovered as a key player in the defense against infectious pathogens, is crucial for inflammation and tissue regeneration. This study aimed to explore the impact of PTX3 gene variants on the development and progression of diabetic neuropathy (DN).

Materials and methods: The potential impact of PTX3 gene variants on the susceptibility to DN was examined by genotyping four single-nucleotide polymorphisms (SNPs) of the PTX3 gene (rs1840680, rs2305619, rs3816527, and rs2120243) in a study involving 730 DN cases and 861 diabetic controls with normal neurologic function.

Results: We demonstrated that diabetic subjects homozygous for the minor allele at rs1840680 [AA; adjusted odds ratio (AOR)=1.486; 95% confidence interval (CI)=1.050-2.103; p=0.02] or rs2120243 (AA; AOR=1.483; 95%CI=1.051-2.091; p=0.025) were more likely to develop neurologic complications compared to those homozygous for the corresponding major allele. Further stratification revealed that this correlation with DN risk was observed specifically in males but not in females. In addition, another SNP of the PTX3 gene, rs2305619, was found to be associated with the risk for DN in males (AA vs. GG, AOR=1.686; 95%CI=1.086-2.617, p=0.020), indicating a sex-specific impact of PTX3 gene polymorphisms on damage to the nerves in diabetic patients. Furthermore, DN patients homozygous for the minor allele of rs1840680 (AA), particularly males, had higher levels of LDL-cholesterol than those homozygous for the reference allele (GG) (p=0.034).

Conclusion: PTX3 gene polymorphisms are associated with dyslipidemia and nerve damage in diabetic patients in a sex-specific manner.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

背景/目的：五羟色胺 3（Pentraxin 3，PTX3）最初是作为抵御感染性病原体的关键角色被发现的，它对炎症和组织再生至关重要。本研究旨在探讨 PTX3 基因变异对糖尿病神经病变（DN）发生和发展的影响：通过对 PTX3 基因的四个单核苷酸多态性（SNPs）（rs1840680、rs2305619、rs3816527 和 rs2120243）进行基因分型，研究了 PTX3 基因变异对 DN 易感性的潜在影响：我们发现，与等位基因相同的糖尿病患者相比，等位基因为 rs1840680 的小等位基因[AA；调整赔率（AOR）=1.486；95% 置信区间（CI）=1.050-2.103；p=0.02]或 rs2120243（AA；AOR=1.483；95%CI=1.051-2.091；p=0.025）的糖尿病患者更容易出现神经系统并发症。进一步分层发现，这种与 DN 风险的相关性只在男性中观察到，而在女性中没有观察到。此外，还发现 PTX3 基因的另一个 SNP rs2305619 与男性的 DN 风险相关（AA 与 GG，AOR=1.686；95%CI=1.086-2.617，p=0.020），这表明 PTX3 基因多态性对糖尿病患者神经损伤的影响具有性别特异性。此外，rs1840680小等位基因（AA）的DN患者，尤其是男性，其低密度脂蛋白胆固醇水平高于参考等位基因（GG）的患者（P=0.034）：结论：PTX3 基因多态性与糖尿病患者的血脂异常和神经损伤有关，且具有性别特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.