Improving pre-operative binary grading: relevance of p53 and PR expression in grade 2 endometrioid endometrial carcinoma.

IF 4.1 2区医学 Q1 OBSTETRICS & GYNECOLOGY International Journal of Gynecological Cancer Pub Date : 2025-02-07 DOI:10.1016/j.ijgc.2025.101682

Puk Meijs-Hermanns, Henrica M J Werner, Loes Kooreman, Petra Bretová, Vit Weinberger, Stephanie Vrede, Luthy S M Alcala, Frédéric Amant, Jasmin Asberger, Markéta Bednaříková, Dorry Boll, Carolien M Bronkhorst, Johan Bulten, Antonio Gil-Moreno, Ingfrid S Haldorsen, Jitka Hausnerová, Jutta Huvila, Martin Koskas, Camilla Krakstad, Heidi Küsters-Vandevelde, Gemma Mancebo Moreno, Xavier Matias-Guiu, Huy Ngo, Brenda M Pijlman, Maria Santacana, Marieke Smink, Jone Trovik, Viola M J Verhoef, Koen Van de Vijver, Dennis van Hamont, Anneke A M van der Wurff, Johanna M A Pijnenborg, Nicole C M Visser

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引用次数: 0

Abstract

Objective: This study aimed to evaluate the association between pre-operative progesterone receptor (PR) and p53 expression and prognosis in pre-operative grade 2 endometrioid endometrial carcinoma compared with grade 1 and grade 3 carcinomas.

Methods: Three European endometrial carcinoma cohort studies were included. Patients with pre-operative grade 2 endometrioid carcinoma and known pre-operative PR and p53 status were included (n = 400), as were patients with pre-operative grade 1 (n = 602) or grade 3 (n = 148) endometrioid carcinomas. Kaplan-Meier and Cox regression analyses were performed to analyze disease-specific and disease-free survival.

Results: Patients with pre-operative grade 2 endometrial carcinoma and wild-type p53 plus PR-positive expression showed a similar 7-year disease-specific survival to grade 1 endometrial carcinoma patients (95.8% vs 97.5%, p = .13), while the 7-year disease-specific survival of patients with grade 2 endometrial carcinoma with p53 aberrant and/or negative PR expression (83.5%) was significantly lower (p < .001). The combination of these markers was an independent prognostic factor in multivariate Cox regression analyses.

Conclusions: The prognostic impact of pre-operative p53 and PR expression in patients with grade 2 endometrioid endometrial carcinoma supports a modified binary grading system in which grade 2 patients should be pre-operatively classified as low- or high-grade depending on p53 and PR expression.

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来源期刊

International Journal of Gynecological Cancer 医学-妇产科学

CiteScore

6.60

自引率

10.40%

发文量

280

审稿时长

3-6 weeks

期刊介绍： The International Journal of Gynecological Cancer, the official journal of the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology, is the primary educational and informational publication for topics relevant to detection, prevention, diagnosis, and treatment of gynecologic malignancies. IJGC emphasizes a multidisciplinary approach, and includes original research, reviews, and video articles. The audience consists of gynecologists, medical oncologists, radiation oncologists, radiologists, pathologists, and research scientists with a special interest in gynecological oncology.