Exploring the Electronic and Steric Effects of Hemilabile (P^N) Ligands in Redox Gold Catalysis: Application to the Cross-Coupling Reaction of Aliphatic Amines with Aryl Iodides
Urvashi, Saurabh Rai, Gaurav Shukla, Nisha, Nitin T. Patil
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引用次数: 0
Abstract
Herein, we report 17 new (P^N) ligands for redox gold catalysis, featuring various substituents at −C4, −C5, and −C6 of the aryl ring and nitrogen handle. Rate kinetics experiments revealed that electron-rich substituents at −C4 and −C5 positions of the aryl ring enhanced the rate of oxidative addition of Au(I) with C(sp2)–Br bonds compared to electron-poor substituents. Further, we report an unprecedented gold-catalyzed arylation of aliphatic amines using an electronically rich ligand (L6) with an −OMe group at the −C5 position.
期刊介绍：
Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.
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