miR-203 Alleviates Myocardial Damage Caused by Acute Coronary Syndrome by Inhibiting CA125

IF 1.6 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemical Genetics Pub Date : 2025-02-28 DOI:10.1007/s10528-025-11069-4

Yanfang Guo, Jinlin Li, Linhao Zhang

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Abstract

Acute coronary syndrome (ACS) is a significant contributor to cardiovascular mortality. Research has indicated that CA125 levels are linked to cardiovascular disease. This study aimed to explore the role of CA125 in ACS and its underlying mechanism. A retrospective study was conducted involving 34 healthy volunteers and 46 patients diagnosed with ACS. Clinical characteristics and CA125 expression were recorded and detected. Bioinformatics analysis was performed to identify miRNAs that regulate CA125. HL-1 cardiac muscle cells were subjected to oxygen–glucose deprivation/reoxygenation (OGD/R) to investigate the role of CA125 in myocardial injury. An ACS mice model was constructed to further explore the role of CA125 on ACS. The levels of serum creatinine, blood urea nitrogen, uric acid, high-sensitivity C-reactive protein, cystatin C, and white blood cells in ACS were markedly higher than those in healthy volunteers. CA125 was up-regulated in ACS and was a target of miR-203. Injection of miR-203 agomir reduced plaque deposition and vascular thrombosis in the coronary lumen, alleviating myocardial damage. Additionally, miR-203 inhibited myocardial apoptosis and inflammation responses induced by OGD/R and ACS. miR-203 can reduce the inflammatory response by inhibiting CA125 expression, thereby improving ACS symptoms and mitigating ACS-induced myocardial injury.

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miR-203通过抑制CA125减轻急性冠状动脉综合征心肌损害

急性冠脉综合征（ACS）是导致心血管疾病死亡的重要因素。研究表明，CA125水平与心血管疾病有关。本研究旨在探讨CA125在ACS中的作用及其潜在机制。对34名健康志愿者和46名确诊为ACS的患者进行了回顾性研究。记录并检测临床特征及CA125表达。生物信息学分析鉴定了调节CA125的mirna。对HL-1心肌细胞进行氧糖剥夺/再氧化（OGD/R），研究CA125在心肌损伤中的作用。建立ACS小鼠模型，进一步探讨CA125在ACS中的作用。ACS患者血清肌酐、尿素氮、尿酸、高敏C反应蛋白、胱抑素C、白细胞水平均明显高于健康志愿者。CA125在ACS中上调，是miR-203的靶标。注射miR-203阿戈莫可减少冠状动脉腔内斑块沉积和血管血栓形成，减轻心肌损伤。此外，miR-203抑制OGD/R和ACS诱导的心肌凋亡和炎症反应。miR-203可以通过抑制CA125的表达来减轻炎症反应，从而改善ACS症状，减轻ACS引起的心肌损伤。

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来源期刊

Biochemical Genetics 生物-生化与分子生物学

CiteScore

3.90

自引率

0.00%

发文量

133

审稿时长

4.8 months

期刊介绍： Biochemical Genetics welcomes original manuscripts that address and test clear scientific hypotheses, are directed to a broad scientific audience, and clearly contribute to the advancement of the field through the use of sound sampling or experimental design, reliable analytical methodologies and robust statistical analyses. Although studies focusing on particular regions and target organisms are welcome, it is not the journal’s goal to publish essentially descriptive studies that provide results with narrow applicability, or are based on very small samples or pseudoreplication. Rather, Biochemical Genetics welcomes review articles that go beyond summarizing previous publications and create added value through the systematic analysis and critique of the current state of knowledge or by conducting meta-analyses. Methodological articles are also within the scope of Biological Genetics, particularly when new laboratory techniques or computational approaches are fully described and thoroughly compared with the existing benchmark methods. Biochemical Genetics welcomes articles on the following topics: Genomics; Proteomics; Population genetics; Phylogenetics; Metagenomics; Microbial genetics; Genetics and evolution of wild and cultivated plants; Animal genetics and evolution; Human genetics and evolution; Genetic disorders; Genetic markers of diseases; Gene technology and therapy; Experimental and analytical methods; Statistical and computational methods.