Márcio Weber Paixão, Till Opatz, Jeimy A C Vélez, Renan O Gonçalves, Pedro H R Oliveira, Robert Forster, Stefanie I Demel, Julio Z Schpector
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Abstract
Herein, we introduce a mild and operationally simple visible-light photochemical protocol for the synthesis of novel glycopeptides mimetics. This method capitalizes on the reaction between 1,4-dihydropyridine (DHP) containing amino acids and peptides with glycosyl nitrones, showing exceptional stereoselectivity and robust performance across a diverse array of substrates, encompassing both modified glycosides and intricate peptide structures. Furthermore, we underscore the versatility of the resultant compounds through their seamless integration and utility in bioconjugation strategies.
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Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields.
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