Ewing Sarcoma Presenting as Fever of Unknown Origin (FUO) in Children: A Case Report and Brief Review of the Literature.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL Clinical Medicine Insights. Case Reports Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI:10.1177/11795476251323164

Hasan Arafat, Zahraa Mm Zeer, Almotazbellah Mm Zeer, Mahmoud Noman, Hamza A Abdul-Hafez, Ahmad G Hammouri, Amer Zughayyer

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Abstract

Introduction: Fever of unknown origin is one of the challenging medical conditions with a wide differential diagnosis.

Case presentation: We present a case of 16-year-old patient with Ewing sarcoma diagnosed with neoplastic fever.

Discussion: Neoplastic fever, which is caused by the tumor itself, is diagnosed when all other causes of fever have been ruled out. It occurs more frequently in hepatic, renal, and hematological cancers. After history and physical examination, a thorough individualized diagnostic approach is required. Removing the underlying cause of fever when feasible and symptomatic relief with NSAIDS are the primary therapeutic approaches.

Conclusion: Fever is common in patients with cancer and it can be due to infectious and non-infectious causes. After excluding all potential causes, neoplastic fever is diagnosed.

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儿童尤文氏肉瘤以不明原因发热（FUO）为表现：1例报告及文献回顾。

来源不明的发热是一种具有挑战性的医学疾病，具有广泛的鉴别诊断。病例介绍：我们报告一位16岁的尤因肉瘤患者，诊断为肿瘤性发热。讨论：肿瘤热是由肿瘤本身引起的，在排除了所有其他发热原因后才被诊断出来。它更常见于肝脏、肾脏和血液肿瘤。在病史和体格检查后，需要一个彻底的个性化诊断方法。在可行的情况下消除发热的根本原因和使用非甾体抗炎药缓解症状是主要的治疗方法。结论：发热在癌症患者中很常见，可由感染性和非感染性原因引起。排除所有可能的原因后，诊断为肿瘤热。

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